DNA replication helicase
Also known as: HELI, ORF55
Function
Component of the helicase/primase complex. Unwinds the DNA at the replication forks and generates single-stranded DNA for both leading and lagging strand synthesis. The primase synthesizes short RNA primers on the lagging strand that the polymerase elongates using dNTPs. Possesses helicase-like motifs and therefore may act as the helicase subunit of the complex.
Classification
- Family (Pfam)
- PF02689 Herpes_Helicase
- InterPro
- DNA_helicase_dom, HSV_HELI, P-loop_NTPase
- Functional cluster
- RNase H & Viral Replication Proteins
Gene Ontology · 5
Drugs targeting this protein · 1
- AMENAMEVIR inhibitor
Related proteins · sequence + function similarity
- DNA replication helicase 1.00
- DNA replication helicase 0.90
- DNA replication helicase 0.84
- DNA replication helicase 0.83
- DNA replication helicase 0.83
- DNA replication helicase 0.83
- DNA replication helicase 0.83
- DNA replication helicase 0.83
- DNA replication helicase 0.82
- DNA replication helicase 0.81
- DNA replication helicase 0.81
- DNA replication helicase 0.80
Co-cited proteins · studied together in the literature
- Cytoplasmic envelopment protein 3 1 shared papers
- Uracil-DNA glycosylase 1 shared papers
- DNA helicase/primase complex-associated protein 1 shared papers
- Transcriptional regulator ICP22 homolog 1 shared papers
- Replication origin-binding protein 1 shared papers
- Nuclear protein UL4 homolog 1 shared papers
- Nuclear phosphoprotein UL3 homolog 1 shared papers
- Uncharacterized protein 57 1 shared papers
- Envelope glycoprotein L 1 shared papers
- Envelope glycoprotein M 1 shared papers
- Envelope protein US9 1 shared papers
- Major viral transcription factor ICP4 homolog 1 shared papers
Literature · 2 cited papers
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