Bcl-2-like protein 10

Function

Promotes cell survival by suppressing apoptosis induced by BAX but not BAK. Increases binding of AHCYL1/IRBIT to ITPR1. Reduces ITPR1-mediated calcium release from the endoplasmic reticulum cooperatively with AHCYL1/IRBIT under normal cellular conditions. Under apoptotic stress conditions, dissociates from ITPR1 and is displaced from mitochondria-associated endoplasmic reticulum membranes, leading to increased Ca(2+) transfer to mitochondria which promotes apoptosis. Required for the correct formation of the microtubule organizing center during oocyte cell division, potentially via regulation of protein abundance and localization of other microtubule organizing center components such as AURKA and TPX2 (By similarity).

Classification

Family (Pfam)

PF00452 Bcl-2

InterPro

Bcl-2-like_sf, Bcl-2_BH1-3, Bcl-2_fam, Bcl2-like, Bcl2_BH1_motif_CS, Bcl2_BH2_motif_CS

Functional cluster

Membrane Channels & Lipid-Anchored Proteins

Experimental structures · PDB · 1

• 4B4S X-ray 1.90A

A predicted model is available from AlphaFold.

Gene Ontology · 20

• GO:0005829 cytosol
• GO:0005783 endoplasmic reticulum
• GO:0016020 membrane
• GO:0044233 mitochondria-associated endoplasmic reticulum membrane contact site
• GO:0005741 mitochondrial outer membrane
• GO:0005739 mitochondrion
• GO:0031965 nuclear membrane
• GO:0005819 spindle
• GO:0005509 calcium ion binding
• GO:0089720 caspase binding
• GO:0015267 channel activity
• GO:0006915 apoptotic process
• GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand
• GO:0007292 female gamete generation
• GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
• GO:0031023 microtubule organizing center organization
• GO:0043066 negative regulation of apoptotic process
• GO:0043065 positive regulation of apoptotic process
• GO:0001836 release of cytochrome c from mitochondria
• GO:0007283 spermatogenesis

Drugs targeting this protein · 1

• OBATOCLAX MESYLATE inhibitor

Related proteins · sequence + function similarity

• Bcl-2-like protein 10 0.81
• Anti-apoptotic protein NR13 0.80
• Bcl-2-like protein 2 0.80
• Bcl-2-like protein 2 0.80
• Anti-apoptotic protein NR13 0.80
• Bcl-2-like protein 2 0.80
• Bcl-2-like protein 2 0.79
• Bcl-2-like protein 12 0.78
• Bcl-2-like protein 10 0.76
• Structure-specific endonuclease ANKLE1 0.72
• GH3 domain-containing protein 0.72
• Osteoclast stimulatory transmembrane protein 0.72

Co-cited proteins · studied together in the literature

• Bcl-2-like protein 11 3 shared papers
• Bcl-2-interacting killer 2 shared papers
• Bcl-2-related protein A1 1 shared papers
• Ubiquilin-1 1 shared papers
• Huntingtin-interacting protein 1-related protein 1 shared papers
• Nucleoside diphosphate kinase B 1 shared papers
• Phorbol-12-myristate-13-acetate-induced protein 1 1 shared papers
• Ubiquilin-4 1 shared papers
• Bcl-2-like protein 10 1 shared papers
• Bcl-2-like protein 10 1 shared papers
• Caspase-9 1 shared papers
• Inositol 1,4,5-trisphosphate-gated calcium channel ITPR2 1 shared papers

Literature · 14 cited papers

• UBQLN4 is an ATM substrate that stabilizes the anti-apoptotic proteins BCL2A1 and BCL2L10 in mesothelioma. Mol. Oncol. · 2021
• IRBIT controls apoptosis by interacting with the Bcl-2 homolog, Bcl2l10, and by promoting ER-mitochondria contact. Elife · 2016
• Polyubiquitination and proteasomal turnover controls the anti-apoptotic activity of Bcl-B. Oncogene · 2013
• The restricted binding repertoire of Bcl-B leaves Bim as the universal BH3-only prosurvival Bcl-2 protein antagonist. Cell Death Dis. · 2012
• The anti-apoptotic Bcl-B protein inhibits BECN1-dependent autophagic cell death. Autophagy · 2012
• Ubiquitination, localization, and stability of an anti-apoptotic BCL2-like protein, BCL2L10/BCLb, are regulated by Ubiquilin1. Proc. Natl. Acad. Sci. U.S.A. · 2012
• Characterization of unique signature sequences in the divergent maternal protein Bcl2l10. Mol. Biol. Evol. · 2011
• HIP1R interacts with a member of Bcl-2 family, BCL2L10, and induces BAK-dependent cell death. Cell. Physiol. Biochem. · 2009
• NM23-H2 involves in negative regulation of Diva and Bcl2L10 in apoptosis signaling. Biochem. Biophys. Res. Commun. · 2007
• Analysis of the DNA sequence and duplication history of human chromosome 15. Nature · 2006
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• Bcl2-L-10, a novel anti-apoptotic member of the Bcl-2 family, blocks apoptosis in the mitochondria death pathway but not in the death receptor pathway. Hum. Mol. Genet. · 2001
• … and 2 more in the literature graph