Bcl-2-like protein 2

Function

Promotes cell survival. Blocks dexamethasone-induced apoptosis. Mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX.

Classification

Family (Pfam)

PF00452 Bcl-2, PF02180 BH4

InterPro

Apop_reg_BclW, Bcl-2-like_sf, Bcl-2_BH1-3, Bcl-2_fam, Bcl2-like, Bcl2_BH1_motif_CS, Bcl2_BH2_motif_CS, Bcl2_BH4, Bcl2_BH4_motif_CS

Functional cluster

Membrane Channels & Lipid-Anchored Proteins

Experimental structures · PDB · 5

• 1MK3 NMR
• 1O0L NMR
• 1ZY3 NMR
• 2Y6W X-ray 2.00A
• 4CIM X-ray 1.50A

A predicted model is available from AlphaFold.

Gene Ontology · 14

• GO:0097136 Bcl-2 family protein complex
• GO:0005829 cytosol
• GO:0005741 mitochondrial outer membrane
• GO:0005739 mitochondrion
• GO:0015267 channel activity
• GO:0097718 disordered domain specific binding
• GO:0042802 identical protein binding
• GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand
• GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
• GO:0043066 negative regulation of apoptotic process
• GO:0043065 positive regulation of apoptotic process
• GO:0042981 regulation of apoptotic process
• GO:0001836 release of cytochrome c from mitochondria
• GO:0007283 spermatogenesis

Drugs targeting this protein · 2

• OBATOCLAX MESYLATE inhibitor
• NAVITOCLAX inhibitor

Related proteins · sequence + function similarity

• Bcl-2-like protein 2 1.00
• Bcl-2-like protein 2 1.00
• Bcl-2-like protein 2 1.00
• Anti-apoptotic protein NR13 0.83
• Apoptosis regulator R1 0.83
• Anti-apoptotic protein NR13 0.82
• Bcl-2-like protein 10 0.80
• Apoptosis regulator R11 0.78
• Bcl-2 homologous antagonist/killer 0.72
• Apoptosis regulator Bcl-2 0.71
• Apoptosis regulator BAX 0.70
• Apoptosis regulator Bcl-2 0.70

Co-cited proteins · studied together in the literature

• Bcl-2-like protein 2 1 shared papers

Literature · 17 cited papers

• An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J. Proteomics · 2014
• Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. Mol. Cell. Proteomics · 2014
• Toward a comprehensive characterization of a human cancer cell phosphoproteome. J. Proteome Res. · 2013
• Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
• Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. Sci. Signal. · 2010
• Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. Sci. Signal. · 2009
• Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. Anal. Chem. · 2009
• A quantitative atlas of mitotic phosphorylation. Proc. Natl. Acad. Sci. U.S.A. · 2008
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004
• Proapoptotic BH3-only proteins trigger membrane integration of prosurvival Bcl-w and neutralize its activity. J. Cell Biol. · 2003
• The structure of Bcl-w reveals a role for the C-terminal residues in modulating biological activity. EMBO J. · 2003
• … and 5 more in the literature graph