Bcl-2-related protein A1

Function

Retards apoptosis induced by IL-3 deprivation. May function in the response of hemopoietic cells to external signals and in maintaining endothelial survival during infection (By similarity). Can inhibit apoptosis induced by serum starvation in the mammary epithelial cell line HC11 (By similarity).

Classification

Family (Pfam)

PF00452 Bcl-2

InterPro

Bcl-2-like_sf, Bcl-2_BH1-3, Bcl-2_fam, Bcl2-like, Bcl2_BH1_motif_CS, Bcl2_BH2_motif_CS, Bcl2A1

Functional cluster

Zinc-Finger & Ubiquitination Proteins

Experimental structures · PDB · 26

• 2VM6 X-ray 2.20A
• 3I1H X-ray 2.20A
• 3MQP X-ray 2.24A
• 4ZEQ X-ray 1.80A
• 5UUK X-ray 1.20A
• 5UUL X-ray 1.33A
• 5UUP X-ray 1.73A
• 5WHH X-ray 2.38A
• 5WHI X-ray 1.69A
• 6E3I X-ray 1.48A
• 6E3J X-ray 1.48A
• 6MBB X-ray 1.59A
• … and 14 more

A predicted model is available from AlphaFold.

Gene Ontology · 10

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005741 mitochondrial outer membrane
• GO:0015267 channel activity
• GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand
• GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
• GO:0008053 mitochondrial fusion
• GO:0043066 negative regulation of apoptotic process
• GO:0043065 positive regulation of apoptotic process
• GO:0001836 release of cytochrome c from mitochondria

Drugs targeting this protein · 1

• OBATOCLAX MESYLATE inhibitor

Related proteins · sequence + function similarity

• Bcl-2-related protein A1 0.94
• Bcl-2-related protein A1 0.93
• Apoptosis regulator Bcl-2 homolog 0.74
• Apoptosis regulator Bcl-2 homolog 0.74
• Apoptosis regulator Bcl-2 homolog 0.74
• Apoptosis regulator Bcl-2 homolog 0.73
• Apoptosis regulator Bcl-2 homolog 0.73
• Apoptosis regulator Bcl-2 homolog 0.73
• Apoptosis regulator Bcl-2 homolog 0.73
• Bcl-2-like protein 15 0.72
• Bcl-2-like protein 15 0.72
• Apoptosis regulator ced-9 0.71

Co-cited proteins · studied together in the literature

• Bcl-2-like protein 11 1 shared papers
• Bcl-2-like protein 10 1 shared papers
• Ubiquilin-4 1 shared papers
• Protein Bop 1 shared papers
• Apoptosis regulator BAX 2 shared papers
• Bcl-2-like protein 1 2 shared papers
• Bcl-2 homologous antagonist/killer 1 shared papers
• Induced myeloid leukemia cell differentiation protein Mcl-1 1 shared papers
• Non-selective voltage-gated ion channel VDAC1 1 shared papers
• Apoptosis regulator Bcl-2 1 shared papers

Literature · 9 cited papers

• UBQLN4 is an ATM substrate that stabilizes the anti-apoptotic proteins BCL2A1 and BCL2L10 in mesothelioma. Mol. Oncol. · 2021
• Human Bop is a novel BH3-only member of the Bcl-2 protein family. Protein Cell · 2012
• Completing the family portrait of the anti-apoptotic Bcl-2 proteins: crystal structure of human Bfl-1 in complex with Bim. FEBS Lett. · 2008
• Analysis of the DNA sequence and duplication history of human chromosome 15. Nature · 2006
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• Characterization of Bax-sigma, a cell death-inducing isoform of Bax. Biochem. Biophys. Res. Commun. · 2000
• GRS, a novel member of the Bcl-2 gene family, is highly expressed in multiple cancer cell lines and in normal leukocytes. Oncogene · 1997
• Cloning of human Bcl-2 homologue: inflammatory cytokines induce human A1 in cultured endothelial cells. Blood · 1996
• A novel Bcl-2 related gene, Bfl-1, is overexpressed in stomach cancer and preferentially expressed in bone marrow. Oncogene · 1995