Bcl-2-like protein 1

Function

Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.

Classification

Family (Pfam)

PF00452 Bcl-2, PF02180 BH4

InterPro

Apop_reg_BclX, Bcl-2-like_sf, Bcl-2_BH1-3, Bcl-2_fam, Bcl2-like, Bcl2/BclX, Bcl2_BH1_motif_CS, Bcl2_BH2_motif_CS, Bcl2_BH3_motif_CS, Bcl2_BH4, Bcl2_BH4_motif_CS

Functional cluster

Membrane Channels & Lipid-Anchored Proteins

Experimental structures · PDB · 114

• 1BXL NMR
• 1G5J NMR
• 1LXL NMR
• 1MAZ X-ray 2.20A
• 1R2D X-ray 1.95A
• 1R2E X-ray 2.10A
• 1R2G X-ray 2.70A
• 1R2H X-ray 2.20A
• 1R2I X-ray 2.00A
• 1YSG NMR
• 1YSI NMR
• 1YSN NMR
• … and 102 more

A predicted model is available from AlphaFold.

Gene Ontology · 38

• GO:0097136 Bcl-2 family protein complex
• GO:0005813 centrosome
• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005783 endoplasmic reticulum
• GO:0005743 mitochondrial inner membrane
• GO:0005759 mitochondrial matrix
• GO:0005741 mitochondrial outer membrane
• GO:0005739 mitochondrion
• GO:0031965 nuclear membrane
• GO:0030672 synaptic vesicle membrane
• GO:0051434 BH3 domain binding
• GO:0015267 channel activity
• GO:0042802 identical protein binding
• GO:0019901 protein kinase binding
• GO:0008637 apoptotic mitochondrial changes
• GO:0051607 defense response to virus
• GO:0006897 endocytosis
• GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand
• GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
• GO:2000811 negative regulation of anoikis
• GO:0043066 negative regulation of apoptotic process
• GO:0010507 negative regulation of autophagy
• GO:1902236 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
• GO:1900118 negative regulation of execution phase of apoptosis
• GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
• GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
• GO:2001243 negative regulation of intrinsic apoptotic signaling pathway
• GO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
• GO:1901029 negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
• GO:1903077 negative regulation of protein localization to plasma membrane
• GO:0090201 negative regulation of release of cytochrome c from mitochondria
• GO:0043065 positive regulation of apoptotic process
• GO:0032465 regulation of cytokinesis
• GO:0046902 regulation of mitochondrial membrane permeability
• GO:0051881 regulation of mitochondrial membrane potential
• GO:0001836 release of cytochrome c from mitochondria
• GO:0034097 response to cytokine

Drugs targeting this protein · 2

• OBATOCLAX MESYLATE inhibitor
• NAVITOCLAX inhibitor

Related proteins · sequence + function similarity

• Bcl-2-like protein 1 1.00
• Bcl-2-like protein 1 1.00
• Bcl-2-like protein 1 1.00
• Bcl-2-like protein 1 0.94
• Apoptosis regulator R11 0.86
• Apoptosis regulator Bcl-2 0.80
• Apoptosis regulator Bcl-2 0.79
• Apoptosis regulator Bcl-2 0.79
• Bcl-2 homologous antagonist/killer 0.77
• Apoptosis regulator R1 0.77
• Apoptosis regulator Bcl-2 0.76
• Apoptosis regulator BAX 0.76

Co-cited proteins · studied together in the literature

• Bcl-2-like protein 1 1 shared papers
• Bcl-2-binding component 3, isoforms 1/2 2 shared papers
• Bcl-2 homologous antagonist/killer 4 shared papers
• Apoptosis regulator Bcl-2 5 shared papers
• Apoptosis regulatory protein Siva 1 shared papers
• Heme-binding protein 2 1 shared papers
• Zinc finger protein Aiolos 1 shared papers
• Bcl2-associated agonist of cell death 2 shared papers
• Bcl-2-related protein A1 2 shared papers
• E3 ubiquitin-protein ligase RNF183 1 shared papers
• E3 ubiquitin-protein ligase RNF183 1 shared papers
• Clusterin 1 shared papers

Literature · 36 cited papers

• Transmembrane E3 ligase RNF183 mediates ER stress-induced apoptosis by degrading Bcl-xL. Proc. Natl. Acad. Sci. U.S.A. · 2018
• The deubiquitinase Usp27x stabilizes the BH3-only protein Bim and enhances apoptosis. EMBO Rep. · 2016
• N-terminome analysis of the human mitochondrial proteome. Proteomics · 2015
• Plasminogen kringle 5 induces endothelial cell apoptosis by triggering a voltage-dependent anion channel 1 (VDAC1) positive feedback loop. J. Biol. Chem. · 2014
• A Bcl-xL-Drp1 complex regulates synaptic vesicle membrane dynamics during endocytosis. Nat. Cell Biol. · 2013
• PUMA binding induces partial unfolding within BCL-xL to disrupt p53 binding and promote apoptosis. Nat. Chem. Biol. · 2013
• Human Bop is a novel BH3-only member of the Bcl-2 protein family. Protein Cell · 2012
• The anti-apoptotic Bcl-B protein inhibits BECN1-dependent autophagic cell death. Autophagy · 2012
• Bcl-xL phosphorylation at Ser49 by polo kinase 3 during cell cycle progression and checkpoints. Cell. Signal. · 2011
• Structural changes in the BH3 domain of SOUL protein upon interaction with the anti-apoptotic protein Bcl-xL. Biochem. J. · 2011
• Human nuclear clusterin mediates apoptosis by interacting with Bcl-XL through C-terminal coiled coil domain. J. Cell. Physiol. · 2012
• Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
• … and 24 more in the literature graph