Aminopeptidase B

Function

Exopeptidase which selectively removes arginine and/or lysine residues from the N-terminus of several peptide substrates including Arg(0)-Leu-enkephalin, Arg(0)-Met-enkephalin and Arg(-1)-Lys(0)-somatostatin-14. Can hydrolyze leukotriene A4 (LTA-4) into leukotriene B4 (LTB-4) (By similarity).

Classification

Family (Pfam)

PF09127 Leuk-A4-hydro_C, PF01433 Peptidase_M1, PF17900 Peptidase_M1_N

InterPro

Aminopeptidase_N-like_N, Aminopeptidase_N-like_N_sf, ARM-type_fold, LTA4H_cat, M1_LTA-4_hydro/amino_C_sf, M1_LTA4H, Peptidase_M1, Peptidase_M1_C, Peptidase_M1_dom, Peptidase_M4/M1_CTD_sf

Functional cluster

Zinc-Finger & Ubiquitination Proteins

Gene Ontology · 10

• GO:0070062 extracellular exosome
• GO:0005576 extracellular region
• GO:0005615 extracellular space
• GO:0005886 plasma membrane
• GO:0004177 aminopeptidase activity
• GO:0004301 epoxide hydrolase activity
• GO:0070006 metalloaminopeptidase activity
• GO:0008235 metalloexopeptidase activity
• GO:0008270 zinc ion binding
• GO:0006508 proteolysis

Drugs targeting this protein · 1

• TOSEDOSTAT inhibitor

Related proteins · sequence + function similarity

• Aminopeptidase B 0.99
• Aminopeptidase B 0.98
• Aminopeptidase RNPEPL1 0.90
• Aminopeptidase RNPEPL1 0.90
• Leukotriene A-4 hydrolase 0.61
• Aminopeptidase O 0.61
• Protein-glucosylgalactosylhydroxylysine glucosidase 0.59
• Leukotriene A-4 hydrolase 0.58
• Leukotriene A-4 hydrolase 0.58
• Aminopeptidase O 0.57
• Protein-glucosylgalactosylhydroxylysine glucosidase 0.56
• Aminopeptidase O 0.56

Literature · 9 cited papers

• An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J. Proteomics · 2014
• Toward a comprehensive characterization of a human cancer cell phosphoproteome. J. Proteome Res. · 2013
• System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. Sci. Signal. · 2011
• Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
• Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. Sci. Signal. · 2010
• Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science · 2009
• The full-ORF clone resource of the German cDNA consortium. BMC Genomics · 2007
• Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. Cell · 2006
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004