Aminopeptidase O

Function

Aminopeptidase which catalyzes the hydrolysis of amino acid residues from the N-terminus of peptide or protein substrates.

Classification

Family (Pfam)

PF09127 Leuk-A4-hydro_C, PF01433 Peptidase_M1

InterPro

Aminopeptidase_N-like_N_sf, AOPep, ARM-type_fold, M1_LTA-4_hydro/amino_C_sf, Peptidase_M1_C, Peptidase_M1_dom, Peptidase_M4/M1_CTD_sf

Functional cluster

Zinc-Finger & Chromatin Regulatory Proteins

Gene Ontology · 5

• GO:0005737 cytoplasm
• GO:0005730 nucleolus
• GO:0070006 metalloaminopeptidase activity
• GO:0008270 zinc ion binding
• GO:0006508 proteolysis

Disease associations

• dystonia 31 MONDO:0030455

Drugs targeting this protein · 1

• TOSEDOSTAT inhibitor

Related proteins · sequence + function similarity

• Aminopeptidase O 0.97
• Aminopeptidase O 0.96
• Transcription initiation factor TFIID subunit 2 0.59
• Aminopeptidase RNPEPL1 0.58
• Aminopeptidase RNPEPL1 0.57
• Aminopeptidase B 0.57
• Aminopeptidase B 0.56
• Prolyl endopeptidase-like 0.56
• Aminopeptidase B 0.55
• PHD finger protein 24 0.54
• Prolyl endopeptidase-like 0.54
• PHD finger protein 24 0.53

Co-cited proteins · studied together in the literature

• Aminopeptidase O 2 shared papers

Literature · 6 cited papers

• Biallelic AOPEP loss-of-function variants cause progressive dystonia with prominent limb involvement. Mov. Disord. · 2022
• PMID 30808004 J. Biol. Chem. · 2019
• Identification of human aminopeptidase O, a novel metalloprotease with structural similarity to aminopeptidase B and leukotriene A4 hydrolase. J. Biol. Chem. · 2005
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• DNA sequence and analysis of human chromosome 9. Nature · 2004
• Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004