Aminopeptidase RNPEPL1

Function

Broad specificity aminopeptidase which preferentially hydrolyzes an N-terminal methionine, citrulline or glutamine.

Classification

Family (Pfam)

PF09127 Leuk-A4-hydro_C, PF01433 Peptidase_M1, PF17900 Peptidase_M1_N

InterPro

Aminopeptidase_N-like_N, Aminopeptidase_N-like_N_sf, ARM-type_fold, LTA4H_cat, M1_LTA-4_hydro/amino_C_sf, M1_LTA4H, Peptidase_M1, Peptidase_M1_C, Peptidase_M1_dom, Peptidase_M4/M1_CTD_sf

Functional cluster

Zinc-Finger & Ubiquitination Proteins

Gene Ontology · 4

• GO:0004239 initiator methionyl aminopeptidase activity
• GO:0070006 metalloaminopeptidase activity
• GO:0008270 zinc ion binding
• GO:0006508 proteolysis

Drugs targeting this protein · 1

• TOSEDOSTAT inhibitor

Related proteins · sequence + function similarity

• Aminopeptidase RNPEPL1 1.00
• Aminopeptidase B 0.90
• Aminopeptidase B 0.88
• Aminopeptidase B 0.88
• Protein-glucosylgalactosylhydroxylysine glucosidase 0.66
• p53-induced death domain-containing protein 1 0.64
• Protein-glucosylgalactosylhydroxylysine glucosidase 0.63
• UMP-CMP kinase 2, mitochondrial 0.62
• Zinc finger MYND domain-containing protein 15 0.62
• Nicotinate phosphoribosyltransferase 0.62
• Carnosine synthase 1 0.62
• Ankyrin repeat domain-containing protein 9 0.62

Co-cited proteins · studied together in the literature

• Calpain-10 1 shared papers
• Calpain-10 1 shared papers
• G protein-coupled receptor 35 1 shared papers
• G protein-coupled receptor 35 1 shared papers

Literature · 7 cited papers

• Arginyl aminopeptidase-like 1 (RNPEPL1) is an alternatively processed aminopeptidase with specificity for methionine, glutamine, and citrulline residues. Protein Pept. Lett. · 2009
• The full-ORF clone resource of the German cDNA consortium. BMC Genomics · 2007
• The consensus coding sequences of human breast and colorectal cancers. Science · 2006
• Generation and annotation of the DNA sequences of human chromosomes 2 and 4. Nature · 2005
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004
• Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus. Nat. Genet. · 2000