Gamma-aminobutyric acid receptor subunit gamma-3

UniProt Q99928 Organism Homo sapiens Gene GABRG3

Also known as: GABRG3

Function

Gamma subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (By similarity). GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s) (By similarity). When activated by GABA, GABAARs selectively allow the flow of chloride across the cell membrane down their electrochemical gradient (By similarity).

Classification

Family (Pfam): PF02931 Neur_chan_LBD, PF02932 Neur_chan_memb
InterPro: GABAA/Glycine_rcpt, GABBAg3_rcpt, GABRG-1/4, Neur_chan_lig-bd, Neur_chan_lig-bd_sf, Neur_channel, Neuro-gated_channel_TM_sf, Neuro_actylchol_rec, Neurotrans-gated_channel_TM, Neurotransmitter_ion_chnl_CS
Functional cluster: Mixed Regulatory & Membrane Proteins

Gene Ontology · 15

Drugs targeting this protein · 66

GLUTETHIMIDE positive modulator
DIAZEPAM positive allosteric modulator
MIDAZOLAM HYDROCHLORIDE positive allosteric modulator
QUAZEPAM positive allosteric modulator
SEVOFLURANE positive allosteric modulator
CHLORDIAZEPOXIDE HYDROCHLORIDE positive allosteric modulator
DESFLURANE positive allosteric modulator
TRICLOFOS SODIUM positive modulator
METHYPRYLON positive allosteric modulator
TALBUTAL positive allosteric modulator
SECOBARBITAL SODIUM positive allosteric modulator
BUTABARBITAL SODIUM positive allosteric modulator
THIAMYLAL SODIUM positive allosteric modulator
ISOFLURANE positive allosteric modulator
ENFLURANE positive modulator
FLUNITRAZEPAM positive allosteric modulator
METHOXYFLURANE positive modulator
ESZOPICLONE positive allosteric modulator
GANAXOLONE positive allosteric modulator
CLOTIAZEPAM positive allosteric modulator
ACAMPROSATE CALCIUM positive modulator
BREXANOLONE positive allosteric modulator
CLORAZEPATE DIPOTASSIUM positive allosteric modulator
ADIPIPLON partial agonist
PAGOCLONE positive allosteric modulator
TETRAZEPAM positive allosteric modulator
ETIFOXINE antagonist
METHAQUALONE HYDROCHLORIDE positive allosteric modulator
RESEQUINIL inverse agonist
TOPIRAMATE positive modulator
METHAQUALONE positive allosteric modulator
ESTAZOLAM positive allosteric modulator
METHOHEXITAL SODIUM positive allosteric modulator
CLOMETHIAZOLE positive allosteric modulator
DARIGABAT agonist
FLURAZEPAM HYDROCHLORIDE positive allosteric modulator
CENOBAMATE positive allosteric modulator
FLUMAZENIL allosteric antagonist
CIPEPOFOL agonist
ZURANOLONE positive allosteric modulator
ABP-700 agonist
PADSEVONIL partial agonist
LOREDIPLON positive allosteric modulator
PENTOBARBITAL positive allosteric modulator
METHARBITAL positive allosteric modulator
CHLORDIAZEPOXIDE positive allosteric modulator
CLONAZEPAM positive allosteric modulator
BUTALBITAL positive allosteric modulator
REMIMAZOLAM BESYLATE positive allosteric modulator
PROPOFOL positive allosteric modulator
OXAZEPAM positive allosteric modulator
LORAZEPAM positive allosteric modulator
ETHCHLORVYNOL positive modulator
TRIAZOLAM positive allosteric modulator
MIDAZOLAM positive allosteric modulator
ALPRAZOLAM positive allosteric modulator
ETOMIDATE positive modulator
CLOBAZAM positive allosteric modulator
THIOPENTAL SODIUM positive allosteric modulator
PRIMIDONE positive allosteric modulator
HALOTHANE positive allosteric modulator
TEMAZEPAM positive allosteric modulator
PRAZEPAM positive allosteric modulator
HALAZEPAM positive allosteric modulator
PENTOBARBITAL SODIUM positive allosteric modulator
MEPROBAMATE agonist

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

VIP36-like protein 1 shared papers
von Willebrand factor A domain-containing protein 3B 1 shared papers
Zinc finger SWIM domain-containing protein 6 1 shared papers
Protein RRP5 homolog 1 shared papers
CUB and sushi domain-containing protein 1 1 shared papers
Protocadherin Fat 1 1 shared papers
Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial 1 shared papers
Zinc finger X-linked protein ZXDA 1 shared papers
Actin remodeling regulator NHS 1 shared papers
Xin actin-binding repeat-containing protein 2 1 shared papers
Matrix-remodeling-associated protein 5 1 shared papers
Striatin-interacting protein 1 1 shared papers

Literature · 4 cited papers

Homozygous missense mutation in the LMAN2L gene segregates with intellectual disability in a large consanguineous Pakistani family. J. Med. Genet. · 2016
Analysis of the DNA sequence and duplication history of human chromosome 15. Nature · 2006
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
Expression and pharmacology of human GABAA receptors containing gamma 3 subunits. Eur. J. Pharmacol. · 1995

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