Cyclin-dependent kinase 15

Function

Serine/threonine-protein kinase that acts like an antiapoptotic protein that counters TRAIL/TNFSF10-induced apoptosis by inducing phosphorylation of BIRC5 at 'Thr-34'.

Classification

Family (Pfam)

PF00069 Pkinase

InterPro

CDK, CDK15_STKc, Kinase-like_dom_sf, Prot_kinase_dom, Protein_kinase_ATP_BS, Ser/Thr_kinase_AS

Functional cluster

Cytochrome P450 & Heme Enzymes

Gene Ontology · 11

• GO:0000307 cyclin-dependent protein kinase holoenzyme complex
• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005634 nucleus
• GO:0005524 ATP binding
• GO:0030332 cyclin binding
• GO:0004693 cyclin-dependent protein serine/threonine kinase activity
• GO:0046872 metal ion binding
• GO:0106310 protein serine kinase activity
• GO:0004674 protein serine/threonine kinase activity
• GO:1901987 regulation of cell cycle phase transition

Drugs targeting this protein · 4

• PHA-793887 inhibitor
• RONICICLIB inhibitor
• AT-7519 inhibitor
• AZD-5438 inhibitor

Related proteins · sequence + function similarity

• Cyclin-dependent kinase 15 0.99
• Cyclin-dependent kinase 15 0.88
• Cyclin-dependent kinase 18 0.82
• Cyclin-dependent kinase 20 0.82
• Cyclin-dependent kinase 18 0.81
• Cyclin-dependent kinase 20 0.81
• Cyclin-dependent kinase 20 0.80
• Cyclin-dependent kinase 14 0.80
• Cyclin-dependent kinase 20 0.80
• Cell division control protein 2 homolog C 0.79
• Cyclin-dependent kinase 7 0.78
• Cyclin-dependent kinase 7 0.78

Co-cited proteins · studied together in the literature

• Baculoviral IAP repeat-containing protein 5 1 shared papers
• Flagellum-associated coiled-coil domain-containing protein 1 1 shared papers
• Protein FAM117B 1 shared papers
• Neurobeachin-like protein 1 1 shared papers
• Islet cell autoantigen 1-like protein 1 shared papers
• Alsin 1 shared papers
• Alsin 1 shared papers
• Calcium-responsive transcription factor 1 shared papers
• Serine/threonine-protein kinase SBK2 1 shared papers
• Uncharacterized serine/threonine-protein kinase SBK3 1 shared papers
• Serine/threonine-protein kinase 40 1 shared papers
• Myosin light chain kinase family member 4 1 shared papers

Literature · 7 cited papers

• ALS2CR7 (CDK15) attenuates TRAIL induced apoptosis by inducing phosphorylation of survivin Thr34. Biochem. Biophys. Res. Commun. · 2014
• Patterns of somatic mutation in human cancer genomes. Nature · 2007
• Generation and annotation of the DNA sequences of human chromosomes 2 and 4. Nature · 2005
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004
• The protein kinase complement of the human genome. Science · 2002
• A gene encoding a putative GTPase regulator is mutated in familial amyotrophic lateral sclerosis 2. Nat. Genet. · 2001