Cyclin-dependent kinase 20

Function

Required for high-level Shh responses in the developing neural tube. Together with TBC1D32, controls the structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing GLI2 to be properly activated in response to SHH signaling (By similarity). Involved in cell growth. Activates CDK2, a kinase involved in the control of the cell cycle, by phosphorylating residue 'Thr-160'.

Classification

Family (Pfam)

PF00069 Pkinase

InterPro

CDK, CDK20-like_STKc, Kinase-like_dom_sf, Prot_kinase_dom, Protein_kinase_ATP_BS, Ser/Thr_kinase_AS

Functional cluster

Serine/Threonine Protein Kinases

Gene Ontology · 9

• GO:0005929 cilium
• GO:0005737 cytoplasm
• GO:0005654 nucleoplasm
• GO:0005634 nucleus
• GO:0005524 ATP binding
• GO:0004693 cyclin-dependent protein serine/threonine kinase activity
• GO:0106310 protein serine kinase activity
• GO:0004674 protein serine/threonine kinase activity
• GO:0051301 cell division

Drugs targeting this protein · 4

• PHA-793887 inhibitor
• RONICICLIB inhibitor
• AT-7519 inhibitor
• AZD-5438 inhibitor

Related proteins · sequence + function similarity

• Cyclin-dependent kinase 20 0.99
• Cyclin-dependent kinase 20 0.99
• Cyclin-dependent kinase 20 0.99
• Cyclin-dependent kinase 20 0.91
• Cyclin-dependent kinase 7 0.90
• Cyclin-dependent kinase 7 0.89
• Cyclin-dependent kinase 7 0.89
• Cyclin-dependent kinase 7 0.89
• Cyclin-dependent kinase D-2 0.88
• Cyclin-dependent kinase 15 0.88
• Cyclin-dependent kinase B1-1 0.87
• Serine/threonine-protein kinase pef1 0.87

Co-cited proteins · studied together in the literature

• Serine/threonine-protein kinase MAK 1 shared papers
• Cyclin-dependent kinase 2 1 shared papers
• Fizzy-related protein homolog 1 shared papers

Literature · 6 cited papers

• Male germ cell-associated kinase is overexpressed in prostate cancer cells and causes mitotic defects via deregulation of APC/C(CDH1). Oncogene · 2012
• Patterns of somatic mutation in human cancer genomes. Nature · 2007
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• DNA sequence and analysis of human chromosome 9. Nature · 2004
• Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004
• p42, a novel cyclin-dependent kinase-activating kinase in mammalian cells. J. Biol. Chem. · 2004