Proteasome subunit alpha-type 8
Also known as: PSMA7L, PSMA8
Function
Component of the spermatoproteasome, a proteasome specifically found in testis that promotes acetylation-dependent degradation of histones, thereby participating actively to the exchange of histones during spermatogenesis. The proteasome is a protein complex that degrades unneeded or damaged proteins by proteolysis, a chemical reaction that breaks peptide bonds. Required for 20S core proteasome assembly, essential for the degradation of meiotic proteins RAD51 and RPA1 at late prophase I and the progression of meiosis I during spermatogenesis. Localizes to the synaptonemal complex, a 'zipper'-like structure that holds homologous chromosome pairs in synapsis during meiotic prophase I.
Classification
- Family (Pfam)
- PF00227 Proteasome, PF10584 Proteasome_A_N
- InterPro
- Ntn_hydrolases_N, Proteasome_alpha, Proteasome_alpha-type, Proteasome_asu_N, Proteasome_sua/b
- Functional cluster
- Small GTPases (Ras/Rab) & related
Gene Ontology · 12
- GO:0005829 cytosol
- GO:0070062 extracellular exosome
- GO:0005634 nucleus
- GO:0019773 proteasome core complex, alpha-subunit complex
- GO:1990111 spermatoproteasome complex
- GO:0030154 cell differentiation
- GO:0030317 flagellated sperm motility
- GO:0051321 meiotic cell cycle
- GO:0010498 proteasomal protein catabolic process
- GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
- GO:0060631 regulation of meiosis I
- GO:0007283 spermatogenesis
Drugs targeting this protein · 7
- OPROZOMIB inhibitor
- IXAZOMIB inhibitor
- BORTEZOMIB inhibitor
- IXAZOMIB CITRATE inhibitor
- MARIZOMIB inhibitor
- CARFILZOMIB inhibitor
- BORTEZOMIB D-MANNITOL inhibitor
Related proteins · sequence + function similarity
- Proteasome subunit alpha type-7-like 0.98
- Proteasome subunit alpha type-8 0.97
- Proteasome subunit alpha type-7 0.95
- Proteasome subunit alpha type-7 0.95
- Proteasome subunit alpha type-7 0.95
- Proteasome subunit alpha type-7 0.95
- Proteasome subunit alpha type-7 0.94
- Proteasome subunit alpha type-7 0.94
- Proteasome subunit alpha type-7 0.94
- Proteasome subunit alpha type-7-B 0.94
- Proteasome subunit alpha type-7-A 0.93
- Proteasome subunit alpha type-7-1 0.93
Literature · 2 cited papers
A document in the lmmol reference corpus — open public data (UniProt, GO, PDB, the literature graph) rendered as a single cross-linked page. Hover any link to preview its target.