Synaptic vesicle glycoprotein 2B
Also known as: KIAA0735, SV2B
Function
Probably plays a role in the control of regulated secretion in neural and endocrine cells.
Classification
- Family (Pfam)
- PF23894 LD_SV2, PF07690 MFS_1, PF00083 Sugar_tr
- InterPro
- LD_SV2, MFS, MFS_dom, MFS_sugar_transport-like, MFS_trans_sf, Sugar_transporter_CS, SV2
- Functional cluster
- Oxidoreductases, Catalases & Peroxidases
Experimental structures · PDB · 6
A predicted model is available from AlphaFold.
Gene Ontology · 10
- GO:0001669 acrosomal vesicle
- GO:0016020 membrane
- GO:0005886 plasma membrane
- GO:0008021 synaptic vesicle
- GO:0030672 synaptic vesicle membrane
- GO:0022857 transmembrane transporter activity
- GO:0007268 chemical synaptic transmission
- GO:0006836 neurotransmitter transport
- GO:0099509 regulation of presynaptic cytosolic calcium ion concentration
- GO:2000300 regulation of synaptic vesicle exocytosis
Drugs targeting this protein · 1
- PADSEVONIL modulator
Related proteins · sequence + function similarity
- Synaptic vesicle glycoprotein 2B 1.00
- Synaptic vesicle glycoprotein 2B 1.00
- Synaptic vesicle glycoprotein 2C 0.92
- Synaptic vesicle glycoprotein 2C 0.92
- Synaptic vesicle glycoprotein 2C 0.92
- Synaptic vesicle glycoprotein 2A 0.84
- Synaptic vesicle glycoprotein 2A 0.83
- Synaptic vesicle glycoprotein 2A 0.83
- Synaptic vesicle glycoprotein 2A 0.83
- Synaptic vesicle glycoprotein 2A 0.83
- Synaptic vesicle glycoprotein 2A 0.83
- Synaptic vesicle 2-related protein 0.70
Co-cited proteins · studied together in the literature
- Synaptic vesicle glycoprotein 2A 1 shared papers
- Synaptic vesicle glycoprotein 2C 1 shared papers
- Botulinum neurotoxin type A2 1 shared papers
- Synaptic vesicle glycoprotein 2B 1 shared papers
- Synaptic vesicle glycoprotein 2A 1 shared papers
Literature · 5 cited papers
- Crystal structure of botulinum neurotoxin A2 in complex with the human protein receptor SV2C reveals plasticity in receptor binding. Toxins · 2018
- Analysis of the DNA sequence and duplication history of human chromosome 15. Nature · 2006
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
- Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004
- Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. DNA Res. · 1998
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