Synaptic vesicle glycoprotein 2C
Also known as: KIAA1054, SV2C
Function
Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles.
Classification
- Family (Pfam)
- PF23894 LD_SV2, PF07690 MFS_1, PF00083 Sugar_tr
- InterPro
- LD_SV2, MFS, MFS_dom, MFS_sugar_transport-like, MFS_trans_sf, Sugar_transporter_CS, SV2
- Functional cluster
- S-Adenosylmethionine Synthases & related
Experimental structures · PDB · 6
A predicted model is available from AlphaFold.
Gene Ontology · 9
- GO:0098691 dopaminergic synapse
- GO:0005654 nucleoplasm
- GO:0005886 plasma membrane
- GO:0008021 synaptic vesicle
- GO:0030672 synaptic vesicle membrane
- GO:0022857 transmembrane transporter activity
- GO:0007268 chemical synaptic transmission
- GO:0006836 neurotransmitter transport
- GO:2000300 regulation of synaptic vesicle exocytosis
Drugs targeting this protein · 1
- PADSEVONIL modulator
Related proteins · sequence + function similarity
- Synaptic vesicle glycoprotein 2C 1.00
- Synaptic vesicle glycoprotein 2C 1.00
- Synaptic vesicle glycoprotein 2B 0.93
- Synaptic vesicle glycoprotein 2B 0.92
- Synaptic vesicle glycoprotein 2B 0.92
- Synaptic vesicle glycoprotein 2A 0.88
- Synaptic vesicle glycoprotein 2A 0.88
- Synaptic vesicle glycoprotein 2A 0.88
- Synaptic vesicle glycoprotein 2A 0.88
- Synaptic vesicle glycoprotein 2A 0.88
- Synaptic vesicle glycoprotein 2A 0.87
- Probable sphingolipid transporter spinster homolog 2 0.70
Co-cited proteins · studied together in the literature
- Botulinum neurotoxin type A 3 shared papers
- Botulinum neurotoxin type A2 2 shared papers
- Synaptic vesicle glycoprotein 2B 1 shared papers
- Synaptic vesicle glycoprotein 2C 2 shared papers
- Synaptic vesicle glycoprotein 2A 1 shared papers
- Synaptic vesicle glycoprotein 2B 2 shared papers
- Synaptic vesicle glycoprotein 2A 2 shared papers
- Beta-1,4 N-acetylgalactosaminyltransferase 1 1 shared papers
- Synaptic vesicle glycoprotein 2C 1 shared papers
- Synaptic vesicle glycoprotein 2A 1 shared papers
- Synaptic vesicle glycoprotein 2B 1 shared papers
- Botulinum neurotoxin type F 1 shared papers
Literature · 8 cited papers
- Crystal structure of botulinum neurotoxin A2 in complex with the human protein receptor SV2C reveals plasticity in receptor binding. Toxins · 2018
- Crystal structure of the BoNT/A2 receptor-binding domain in complex with the luminal domain of its neuronal receptor SV2C. Sci. Rep. · 2017
- Only the complex N559-glycan in the synaptic vesicle glycoprotein 2C mediates high affinity binding to botulinum neurotoxin serotype A1. Biochem. J. · 2016
- N-linked glycosylation of SV2 is required for binding and uptake of botulinum neurotoxin A. Nat. Struct. Mol. Biol. · 2016
- Structural basis for recognition of synaptic vesicle protein 2C by botulinum neurotoxin A. Nature · 2014
- Botulinum neurotoxin D uses synaptic vesicle protein SV2 and gangliosides as receptors. PLoS Pathog. · 2011
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
- Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. DNA Res. · 1999
A document in the lmmol reference corpus — open public data (UniProt, GO, PDB, the literature graph) rendered as a single cross-linked page. Hover any link to preview its target.