Synaptic vesicle glycoprotein 2A

Function

Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles (By similarity).

Classification

Family (Pfam)

PF23894 LD_SV2, PF07690 MFS_1, PF00083 Sugar_tr

InterPro

LD_SV2, MFS, MFS_dom, MFS_sugar_transport-like, MFS_trans_sf, Sugar_transporter_CS, SV2

Functional cluster

Membrane Transporters & GPCRs

Experimental structures · PDB · 18

• 4V11 X-ray 1.95A
• 8JLC EM 2.88A
• 8JLE EM 2.82A
• 8JLF EM 3.01A
• 8JLG EM 2.87A
• 8JLH EM 2.90A
• 8JLI EM 3.38A
• 8JS8 EM 2.88A
• 8JS9 EM 3.01A
• 8K77 EM 3.11A
• 8UO9 EM 3.30A
• 8UOA EM 3.80A
• … and 6 more

A predicted model is available from AlphaFold.

Gene Ontology · 13

• GO:0005911 cell-cell junction
• GO:0005783 endoplasmic reticulum
• GO:0098982 GABA-ergic synapse
• GO:0098978 glutamatergic synapse
• GO:0031594 neuromuscular junction
• GO:0043005 neuron projection
• GO:0005886 plasma membrane
• GO:0048786 presynaptic active zone
• GO:0008021 synaptic vesicle
• GO:0030672 synaptic vesicle membrane
• GO:0019901 protein kinase binding
• GO:0022857 transmembrane transporter activity
• GO:0016082 synaptic vesicle priming

Disease associations

• developmental and epileptic encephalopathy 113 MONDO:0958330

Drugs targeting this protein · 4

• LEVETIRACETAM modulator
• SELETRACETAM modulator
• PADSEVONIL modulator
• BRIVARACETAM modulator

Related proteins · sequence + function similarity

• Synaptic vesicle glycoprotein 2A 1.00
• Synaptic vesicle glycoprotein 2A 1.00
• Synaptic vesicle glycoprotein 2A 1.00
• Synaptic vesicle glycoprotein 2A 1.00
• Synaptic vesicle glycoprotein 2A 1.00
• Synaptic vesicle glycoprotein 2C 0.89
• Synaptic vesicle glycoprotein 2C 0.89
• Synaptic vesicle glycoprotein 2C 0.88
• Synaptic vesicle glycoprotein 2B 0.84
• Synaptic vesicle glycoprotein 2B 0.84
• Synaptic vesicle glycoprotein 2B 0.83
• Synaptic vesicle 2-related protein 0.73

Co-cited proteins · studied together in the literature

• Synaptic vesicle glycoprotein 2A 2 shared papers
• Synaptic vesicle glycoprotein 2B 1 shared papers
• Synaptic vesicle glycoprotein 2C 1 shared papers
• Botulinum neurotoxin type A2 1 shared papers
• Synaptic vesicle glycoprotein 2B 1 shared papers

Literature · 10 cited papers

• Biallelic variants in the synaptic vesicle glycoprotein 2 A are associated with epileptic encephalopathy. Eur. J. Hum. Genet. · 2024
• Crystal structure of botulinum neurotoxin A2 in complex with the human protein receptor SV2C reveals plasticity in receptor binding. Toxins · 2018
• Homozygous Mutation in Synaptic Vesicle Glycoprotein 2A Gene Results in Intractable Epilepsy, Involuntary Movements, Microcephaly, and Developmental and Growth Retardation. Pediatr. Neurol. · 2015
• Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. Sci. Signal. · 2009
• The full-ORF clone resource of the German cDNA consortium. BMC Genomics · 2007
• The DNA sequence and biological annotation of human chromosome 1. Nature · 2006
• Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. DNA Res. · 2005
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• The synaptic vesicle protein SV2A is the binding site for the antiepileptic drug levetiracetam. Proc. Natl. Acad. Sci. U.S.A. · 2004
• Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. DNA Res. · 1998