Aminopeptidase Q

Function

Metalloprotease which may be important for placentation by regulating biological activity of key peptides at the embryo-maternal interface. On synthetic substrates it shows a marked preference for Leu-4-methylcoumaryl-7-amide (Leu-MCA) over Met-MCA, Arg-LCA and Lys-LCA. Cleaves the N-terminal amino acid of several peptides such as angiotensin-3, kisspeptin-10 and endokinin C.

Classification

Family (Pfam)

PF11838 ERAP1_C, PF01433 Peptidase_M1, PF17900 Peptidase_M1_N

InterPro

Aminopeptidase_N-like_N, Aminopeptidase_N-like_N_sf, ERAP1-like_C_dom, M1_APN-typ, Peptidase_M1, Peptidase_M1_aminopeptidases, Peptidase_M1_dom, Peptidase_M4/M1_CTD_sf

Functional cluster

Immunoglobulin-Domain Cell Adhesion Proteins

Gene Ontology · 6

• GO:0005615 extracellular space
• GO:0016020 membrane
• GO:0070006 metalloaminopeptidase activity
• GO:0008270 zinc ion binding
• GO:0043171 peptide catabolic process
• GO:0006508 proteolysis

Drugs targeting this protein · 1

• TOSEDOSTAT inhibitor

Related proteins · sequence + function similarity

• Aminopeptidase Q 0.98
• Aminopeptidase Q 0.97
• Leucyl-cystinyl aminopeptidase 0.88
• Leucyl-cystinyl aminopeptidase 0.87
• Leucyl-cystinyl aminopeptidase 0.87
• Endoplasmic reticulum aminopeptidase 2 0.86
• Endoplasmic reticulum aminopeptidase 2 0.86
• Endoplasmic reticulum aminopeptidase 1 0.85
• Endoplasmic reticulum aminopeptidase 2 0.85
• Glutamyl aminopeptidase 0.85
• Endoplasmic reticulum aminopeptidase 1 0.85
• Aminopeptidase Q 0.84

Literature · 5 cited papers

• Laeverin/aminopeptidase Q, a novel bestatin-sensitive leucine aminopeptidase belonging to the M1 family of aminopeptidases. J. Biol. Chem. · 2007
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• The DNA sequence and comparative analysis of human chromosome 5. Nature · 2004
• Human extravillous trophoblasts express laeverin, a novel protein that belongs to membrane-bound gluzincin metallopeptidases. Biochem. Biophys. Res. Commun. · 2004
• Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004