lmmol · Proteins

Endoplasmic reticulum aminopeptidase 1

UniProt Q9NZ08 Organism Homo sapiens Gene APPILS, ARTS1, ERAP1, KIAA0525 EC 3.4.11.-

Also known as: APPILS, ARTS1, ERAP1, KIAA0525

Function

Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Strongly prefers substrates 9-16 residues long. Rapidly degrades 13-mer to a 9-mer and then stops. Preferentially hydrolyzes the residue Leu and peptides with a hydrophobic C-terminus, while it has weak activity toward peptides with charged C-terminus. May play a role in the inactivation of peptide hormones. May be involved in the regulation of blood pressure through the inactivation of angiotensin II and/or the generation of bradykinin in the kidney.

Classification

Family (Pfam)
PF11838 ERAP1_C, PF01433 Peptidase_M1, PF17900 Peptidase_M1_N
InterPro
Aminopeptidase_N-like_N, Aminopeptidase_N-like_N_sf, ERAP1-like_C_dom, M1_APN-typ, Peptidase_M1, Peptidase_M1_aminopeptidases, Peptidase_M1_dom, Peptidase_M4/M1_CTD_sf
Functional cluster
Immunoglobulin-Domain Cell Adhesion Proteins

Experimental structures · PDB · 18

A predicted model is available from AlphaFold.

Gene Ontology · 26

Drugs targeting this protein · 1

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Literature · 14 cited papers

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