Glutamyl aminopeptidase

Function

Regulates central hypertension through its calcium-modulated preference to cleave N-terminal acidic residues from peptides such as angiotensin II.

Classification

Family (Pfam)

PF11838 ERAP1_C, PF01433 Peptidase_M1, PF17900 Peptidase_M1_N

InterPro

Aminopeptidase_N-like_N, Aminopeptidase_N-like_N_sf, ERAP1-like_C_dom, M1_APN-typ, Peptidase_M1, Peptidase_M1_aminopeptidases, Peptidase_M1_dom, Peptidase_M4/M1_CTD_sf

Functional cluster

Secreted Hydrolases & Toxins

Experimental structures · PDB · 7

• 4KX7 X-ray 2.15A
• 4KX8 X-ray 2.40A
• 4KX9 X-ray 2.25A
• 4KXA X-ray 2.40A
• 4KXB X-ray 2.40A
• 4KXC X-ray 2.40A
• 4KXD X-ray 2.15A

A predicted model is available from AlphaFold.

Gene Ontology · 21

• GO:0045177 apical part of cell
• GO:0016324 apical plasma membrane
• GO:0005903 brush border
• GO:0031410 cytoplasmic vesicle
• GO:0009897 external side of plasma membrane
• GO:0070062 extracellular exosome
• GO:0005615 extracellular space
• GO:0005765 lysosomal membrane
• GO:0005886 plasma membrane
• GO:0004177 aminopeptidase activity
• GO:0004230 glutamyl aminopeptidase activity
• GO:0070006 metalloaminopeptidase activity
• GO:0008270 zinc ion binding
• GO:0001525 angiogenesis
• GO:0002003 angiotensin maturation
• GO:0016477 cell migration
• GO:0008283 cell population proliferation
• GO:0007267 cell-cell signaling
• GO:0032835 glomerulus development
• GO:0043171 peptide catabolic process
• GO:0003081 regulation of systemic arterial blood pressure by renin-angiotensin

Drugs targeting this protein · 2

• TOSEDOSTAT inhibitor
• FIRIBASTAT inhibitor

Related proteins · sequence + function similarity

• Glutamyl aminopeptidase 0.98
• Glutamyl aminopeptidase 0.98
• Glutamyl aminopeptidase 0.98
• Glutamyl aminopeptidase 0.97
• Aminopeptidase A 0.96
• Glutamyl aminopeptidase 0.96
• Aminopeptidase N 0.94
• Aminopeptidase N 0.93
• Endoplasmic reticulum aminopeptidase 1 0.92
• Aminopeptidase N 0.92
• Aminopeptidase N 0.92
• Endoplasmic reticulum aminopeptidase 1 0.91

Literature · 10 cited papers

• Structural insights into central hypertension regulation by human aminopeptidase A. J. Biol. Chem. · 2013
• Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
• Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. J. Proteome Res. · 2009
• The consensus coding sequences of human breast and colorectal cancers. Science · 2006
• Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. J. Proteome Res. · 2005
• Generation and annotation of the DNA sequences of human chromosomes 2 and 4. Nature · 2005
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• Expression of aminopeptidase A in human gestational choriocarcinoma cell lines and tissues. Placenta · 2000
• Molecular cloning of the human kidney differentiation antigen gp160: human aminopeptidase A. Proc. Natl. Acad. Sci. U.S.A. · 1993
• cDNA cloning and expression of human glutamyl aminopeptidase (aminopeptidase A). Genomics · 1993