Aminopeptidase N

UniProt P15144 Organism Homo sapiens Gene ANPEP, APN, CD13, PEPN EC 3.4.11.2

Also known as: ANPEP, APN, CD13, PEPN

Function

Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis and promote cholesterol crystallization. May have a role in amino acid transport by acting as binding partner of amino acid transporter SLC6A19 and regulating its activity (By similarity).

Classification

Family (Pfam): PF11838 ERAP1_C, PF01433 Peptidase_M1, PF17900 Peptidase_M1_N
InterPro: Aminopeptidase_N-like_N, Aminopeptidase_N-like_N_sf, ERAP1-like_C_dom, M1_APN-typ, Peptidase_M1, Peptidase_M1_aminopeptidases, Peptidase_M1_dom, Peptidase_M4/M1_CTD_sf
Functional cluster: Secreted Hydrolases & Toxins

Experimental structures · PDB · 15

4FYQ X-ray 1.90A
4FYR X-ray 1.91A
4FYS X-ray 2.01A
4FYT X-ray 1.85A
5LHD X-ray 2.60A
6ATK X-ray 3.50A
6U7E X-ray 3.00A
6U7F X-ray 2.75A
6U7G X-ray 2.35A
6XWD X-ray 1.60A
7AEW X-ray 1.20A
7VPQ X-ray 3.10A
… and 3 more

A predicted model is available from AlphaFold.

Gene Ontology · 18

Drugs targeting this protein · 1

TOSEDOSTAT inhibitor

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Spike glycoprotein 2 shared papers
Beta-2-glycoprotein 1 1 shared papers
IgGFc-binding protein 1 shared papers
Zinc-alpha-2-glycoprotein 1 shared papers
Hemopexin 1 shared papers
Antithrombin-III 1 shared papers
Ceruloplasmin 1 shared papers
Pantetheinase 1 shared papers
Alpha-1-acid glycoprotein 1 1 shared papers
Alpha-1-acid glycoprotein 2 1 shared papers
Polymeric immunoglobulin receptor 1 shared papers
Neutrophil gelatinase-associated lipocalin 1 shared papers

Literature · 29 cited papers

N-terminome analysis of the human mitochondrial proteome. Proteomics · 2015
An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J. Proteomics · 2014
The X-ray crystal structure of human aminopeptidase N reveals a novel dimer and the basis for peptide processing. J. Biol. Chem. · 2012
Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. J. Proteome Res. · 2009
Analysis of the DNA sequence and duplication history of human chromosome 15. Nature · 2006
Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. J. Proteome Res. · 2005
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
A proteomic analysis of human bile. Mol. Cell. Proteomics · 2004
Identification of a receptor-binding domain of the spike glycoprotein of human coronavirus HCoV-229E. J. Virol. · 2003
Soluble aminopeptidase N/CD13 in malignant and nonmalignant effusions and intratumoral fluid. Clin. Cancer Res. · 2002
Molecular determinants of species specificity in the coronavirus receptor aminopeptidase N (CD13): influence of N-linked glycosylation. J. Virol. · 2001
… and 17 more in the literature graph

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