DNA topoisomerase 4 subunit B
Also known as: SP_0852, parE
Function
Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.
Classification
- Family (Pfam)
- PF00204 DNA_gyraseB, PF00986 DNA_gyraseB_C, PF02518 HATPase_c, PF01751 Toprim
- InterPro
- DNA_gyrase_B_C, HATPase_C_sf, HATPase_dom, ParE_type2, Ribosomal_Su5_D2-typ_SF, Ribsml_uS5_D2-typ_fold_subgr, Topo_IIA, Topo_IIA-like_dom_sf, Topo_IIA_B, Topo_IIA_B_C, Topo_IIA_bsu_dom2, TopoIIA_CS, TOPRIM_dom
- Functional cluster
- S-Adenosylmethionine Synthases & related
Experimental structures · PDB · 20
- 3FOE X-ray 4.00A
- 3FOF X-ray 4.00A
- 3K9F X-ray 2.90A
- 3KSA X-ray 3.30A
- 3KSB X-ray 3.50A
- 3LTN X-ray 3.10A
- 3RAD X-ray 3.35A
- 3RAE X-ray 2.90A
- 3RAF X-ray 3.24A
- 4I3H X-ray 3.70A
- 4JUO X-ray 6.53A
- 4KOE X-ray 3.02A
- … and 8 more
A predicted model is available from AlphaFold.
Gene Ontology · 7
Drugs targeting this protein · 4
- GREPAFLOXACIN HYDROCHLORIDE inhibitor
- GEMIFLOXACIN MESYLATE inhibitor
- GATIFLOXACIN inhibitor
- LEVOFLOXACIN inhibitor
Related proteins · sequence + function similarity
- DNA topoisomerase 4 subunit B 0.95
- DNA topoisomerase 4 subunit B 0.95
- DNA topoisomerase 4 subunit B 0.94
- DNA topoisomerase 4 subunit B 0.94
- DNA topoisomerase 4 subunit B 0.94
- DNA topoisomerase 4 subunit B 0.94
- DNA topoisomerase 4 subunit B 0.94
- DNA topoisomerase 4 subunit B 0.94
- DNA topoisomerase 4 subunit B 0.94
- DNA topoisomerase 4 subunit B 0.94
- DNA topoisomerase 4 subunit B 0.94
- DNA gyrase subunit B 0.92
Co-cited proteins · studied together in the literature
- DNA topoisomerase 4 subunit A 5 shared papers
- Glycerol-3-phosphate acyltransferase 1 shared papers
Literature · 6 cited papers
- Structural basis of gate-DNA breakage and resealing by type II topoisomerases. PLoS ONE · 2010
- Structural insight into the quinolone-DNA cleavage complex of type IIA topoisomerases. Nat. Struct. Mol. Biol. · 2009
- Breakage-reunion domain of Streptococcus pneumoniae topoisomerase IV: crystal structure of a gram-positive quinolone target. PLoS ONE · 2007
- Complete genome sequence of a virulent isolate of Streptococcus pneumoniae. Science · 2001
- ParC subunit of DNA topoisomerase IV of Streptococcus pneumoniae is a primary target of fluoroquinolones and cooperates with DNA gyrase A subunit in forming resistance phenotype. Antimicrob. Agents Chemother. · 1996
- Cloning and characterization of the parC and parE genes of Streptococcus pneumoniae encoding DNA topoisomerase IV: role in fluoroquinolone resistance. J. Bacteriol. · 1996
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