DNA topoisomerase 4 subunit A
Also known as: SP_0855, parC
Function
Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.
Classification
- Family (Pfam)
- PF03989 DNA_gyraseA_C, PF00521 DNA_topoisoIV
- InterPro
- GyrA/parC_rep, Gyrase/topoIV_suA_C, Topo_IIA-like_dom_sf, Topo_IIA_A/C_ab, Topo_IIA_A_a_sf, Topo_IIA_dom_A, TopoIV_A_Gpos, Type_II_DNA_Topoisomerases
- Functional cluster
- DNA Mismatch Repair & Segregation Proteins
Experimental structures · PDB · 22
- 2NOV X-ray 2.67A
- 3FOE X-ray 4.00A
- 3FOF X-ray 4.00A
- 3K9F X-ray 2.90A
- 3KSA X-ray 3.30A
- 3KSB X-ray 3.50A
- 3LTN X-ray 3.10A
- 3RAD X-ray 3.35A
- 3RAE X-ray 2.90A
- 3RAF X-ray 3.24A
- 4I3H X-ray 3.70A
- 4JUO X-ray 6.53A
- … and 10 more
A predicted model is available from AlphaFold.
Gene Ontology · 9
- GO:0005694 chromosome
- GO:0005737 cytoplasm
- GO:0009330 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex
- GO:0019897 extrinsic component of plasma membrane
- GO:0005524 ATP binding
- GO:0003677 DNA binding
- GO:0034335 DNA negative supercoiling activity
- GO:0007059 chromosome segregation
- GO:0006265 DNA topological change
Drugs targeting this protein · 4
- GREPAFLOXACIN HYDROCHLORIDE inhibitor
- GEMIFLOXACIN MESYLATE inhibitor
- GATIFLOXACIN inhibitor
- LEVOFLOXACIN inhibitor
Related proteins · sequence + function similarity
- DNA topoisomerase 4 subunit A 0.94
- DNA topoisomerase 4 subunit A 0.94
- DNA topoisomerase 4 subunit A 0.93
- DNA topoisomerase 4 subunit A 0.93
- DNA topoisomerase 4 subunit A 0.93
- DNA topoisomerase 4 subunit A 0.88
- DNA topoisomerase 4 subunit A 0.88
- DNA topoisomerase 4 subunit A 0.87
- DNA topoisomerase 4 subunit A 0.87
- DNA topoisomerase 4 subunit A 0.87
- DNA topoisomerase 4 subunit A 0.87
- DNA topoisomerase 4 subunit A 0.87
Co-cited proteins · studied together in the literature
- DNA topoisomerase 4 subunit B 5 shared papers
- Glycerol-3-phosphate acyltransferase 1 shared papers
Literature · 7 cited papers
- Structural basis of gate-DNA breakage and resealing by type II topoisomerases. PLoS ONE · 2010
- Structural insight into the quinolone-DNA cleavage complex of type IIA topoisomerases. Nat. Struct. Mol. Biol. · 2009
- Breakage-reunion domain of Streptococcus pneumoniae topoisomerase IV: crystal structure of a gram-positive quinolone target. PLoS ONE · 2007
- Complete genome sequence of a virulent isolate of Streptococcus pneumoniae. Science · 2001
- Contribution of mutations in gyrA and parC genes to fluoroquinolone resistance of mutants of Streptococcus pneumoniae obtained in vivo and in vitro. Antimicrob. Agents Chemother. · 1996
- ParC subunit of DNA topoisomerase IV of Streptococcus pneumoniae is a primary target of fluoroquinolones and cooperates with DNA gyrase A subunit in forming resistance phenotype. Antimicrob. Agents Chemother. · 1996
- Cloning and characterization of the parC and parE genes of Streptococcus pneumoniae encoding DNA topoisomerase IV: role in fluoroquinolone resistance. J. Bacteriol. · 1996
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