DNA topoisomerase 4 subunit A
Also known as: SpyM3_0625, parC
Function
Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.
Classification
- Family (Pfam)
- PF03989 DNA_gyraseA_C, PF00521 DNA_topoisoIV
- InterPro
- GyrA/parC_rep, Gyrase/topoIV_suA_C, Topo_IIA-like_dom_sf, Topo_IIA_A/C_ab, Topo_IIA_A_a_sf, Topo_IIA_dom_A, TopoIV_A_Gpos, Type_II_DNA_Topoisomerases
- Functional cluster
- DNA Mismatch Repair & Segregation Proteins
Gene Ontology · 9
- GO:0005694 chromosome
- GO:0005737 cytoplasm
- GO:0009330 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex
- GO:0019897 extrinsic component of plasma membrane
- GO:0005524 ATP binding
- GO:0003677 DNA binding
- GO:0034335 DNA negative supercoiling activity
- GO:0007059 chromosome segregation
- GO:0006265 DNA topological change
Drugs targeting this protein · 1
- OZENOXACIN inhibitor
Related proteins · sequence + function similarity
- DNA topoisomerase 4 subunit A 1.00
- DNA topoisomerase 4 subunit A 1.00
- DNA topoisomerase 4 subunit A 1.00
- DNA topoisomerase 4 subunit A 1.00
- DNA topoisomerase 4 subunit A 0.93
- DNA topoisomerase 4 subunit A 0.89
- DNA topoisomerase 4 subunit A 0.89
- DNA topoisomerase 4 subunit A 0.89
- DNA topoisomerase 4 subunit A 0.89
- DNA topoisomerase 4 subunit A 0.88
- DNA topoisomerase 4 subunit A 0.88
- DNA topoisomerase 4 subunit A 0.88
Literature · 1 cited papers
- Genome sequence of a serotype M3 strain of group A Streptococcus: phage-encoded toxins, the high-virulence phenotype, and clone emergence. Proc. Natl. Acad. Sci. U.S.A. · 2002
A document in the lmmol reference corpus — open public data (UniProt, GO, PDB, the literature graph) rendered as a single cross-linked page. Hover any link to preview its target.