lmmol · Proteins

Ryanodine receptor 3

UniProt Q15413 Organism Homo sapiens Gene HBRR, RYR3

Also known as: HBRR, RYR3

Function

Cytosolic calcium-activated calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm in muscle and thereby plays a role in triggering muscle contraction. May regulate Ca(2+) release by other calcium channels. Calcium channel that mediates Ca(2+)-induced Ca(2+) release from the endoplasmic reticulum in non-muscle cells. Contributes to cellular calcium ion homeostasis (By similarity). Plays a role in cellular calcium signaling.

Classification

Family (Pfam)
PF08709 Ins145_P3_rec, PF00520 Ion_trans, PF02815 MIR, PF08454 RIH_assoc, PF06459 RR_TM4-6, PF01365 RYDR_ITPR, PF21119 RYDR_Jsol, PF02026 RyR, PF00622 SPRY
InterPro
ARM-type_fold, B30.2/SPRY, B30.2/SPRY_sf, ConA-like_dom_sf, EF-hand-dom_pair, EF_hand_dom, Ins145_P3_rcpt, Ion_trans_dom, MIR_dom_sf, MIR_motif, RIH_assoc-dom, RIH_dom, Ryan_recept, Ryanodine_IP3_receptor, Ryanodine_rcpt, Ryanrecept_TM4-6, RYDR_Jsol, RyR/IP3R_RIH_dom_sf, SPRY1_RyR, SPRY2_RyR, SPRY3_RyR, SPRY_dom
Functional cluster
S-Adenosylmethionine Synthases & related

Experimental structures · PDB · 10

A predicted model is available from AlphaFold.

Gene Ontology · 22

Disease associations

Drugs targeting this protein · 1

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Literature · 12 cited papers

A document in the lmmol reference corpus — open public data (UniProt, GO, PDB, the literature graph) rendered as a single cross-linked page. Hover any link to preview its target.