Ryanodine receptor 1

UniProt P11716 Organism Oryctolagus cuniculus Gene RYR1

Also known as: RYR1

Function

Cytosolic calcium-activated calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytosol and thereby plays a key role in triggering muscle contraction following depolarization of T-tubules. Repeated very high-level exercise increases the open probability of the channel and leads to Ca(2+) leaking into the cytoplasm (By similarity). Can also mediate the release of Ca(2+) from intracellular stores in neurons, and may thereby promote prolonged Ca(2+) signaling in the brain. Required for normal embryonic development of muscle fibers and skeletal muscle. Required for normal heart morphogenesis, skin development and ossification during embryogenesis (By similarity).

Classification

Family (Pfam): PF08709 Ins145_P3_rec, PF00520 Ion_trans, PF02815 MIR, PF08454 RIH_assoc, PF06459 RR_TM4-6, PF01365 RYDR_ITPR, PF21119 RYDR_Jsol, PF02026 RyR, PF00622 SPRY
InterPro: B30.2/SPRY, B30.2/SPRY_sf, ConA-like_dom_sf, EF-hand-dom_pair, Ins145_P3_rcpt, Ion_trans_dom, MIR_dom_sf, MIR_motif, RIH_assoc-dom, RIH_dom, Ryan_recept, Ryanodine_IP3_receptor, Ryanodine_rcpt, Ryanrecept_TM4-6, RYDR_Jsol, RyR/IP3R_RIH_dom_sf, SPRY1_RyR, SPRY2_RyR, SPRY3_RyR, SPRY_dom
Functional cluster: Zinc-Finger & Ubiquitination Proteins

Experimental structures · PDB · 124

2BCX X-ray 2.00A
2XOA X-ray 2.50A
3HSM X-ray 2.50A
3ILA X-ray 2.90A
3J8H EM 3.80A
3RQR X-ray 2.16A
4ERT X-ray 1.95A
4ESU X-ray 1.59A
4ETT X-ray 2.20A
4ETU X-ray 2.19A
4I0Y X-ray 2.80A
4I1E X-ray 2.40A
… and 112 more

A predicted model is available from AlphaFold.

Gene Ontology · 34

Neighborhood · nearest proteins

Nearest neighbours of Ryanodine receptor 1: 3 by sequence/function similarity (left); 3 co-cited in the literature (right).

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Peptidyl-prolyl cis-trans isomerase FKBP1A 4 shared papers
Ryanodine receptor 2 3 shared papers
Ryanodine receptor 1 2 shared papers
Ryanodine receptor 2 2 shared papers
Ryanodine receptor 3 2 shared papers
Ryanodine receptor 1 1 shared papers
Voltage-dependent L-type calcium channel subunit beta-1 1 shared papers
Triadin 1 shared papers
Voltage-dependent L-type calcium channel subunit alpha-1S 1 shared papers
Ryanodine receptor 3 1 shared papers
Calsequestrin-1 1 shared papers
Selenoprotein N 1 shared papers

Literature · 35 cited papers

Structural basis for gating and activation of RyR1. Cell · 2016
Structural insights into Ca(2+)-activated long-range allosteric channel gating of RyR1. Cell Res. · 2016
The central domain of RyR1 is the transducer for long-range allosteric gating of channel opening. Cell Res. · 2016
Structure-function relationships of peptides forming the calcin family of ryanodine receptor ligands. J. Gen. Physiol. · 2016
Crystal structures of ryanodine receptor SPRY1 and tandem-repeat domains reveal a critical FKBP12 binding determinant. Nat. Commun. · 2015
Structure of the rabbit ryanodine receptor RyR1 at near-atomic resolution. Nature · 2015
Architecture and conformational switch mechanism of the ryanodine receptor. Nature · 2015
Crystal structures of wild type and disease mutant forms of the ryanodine receptor SPRY2 domain. Nat. Commun. · 2014
Disease mutations in the ryanodine receptor N-terminal region couple to a mobile intersubunit interface. Nat. Commun. · 2013
Structural determination of the phosphorylation domain of the ryanodine receptor. FEBS J. · 2012
Disease mutations in the ryanodine receptor central region: crystal structures of a phosphorylation hot spot domain. Structure · 2012
Nitric oxide-induced calcium release via ryanodine receptors regulates neuronal function. EMBO J. · 2012
… and 23 more in the literature graph

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