Peptidyl-prolyl cis-trans isomerase FKBP1A
Also known as: FKBP1, FKBP12, FKBP1A
Function
Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruits SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Classification
- Family (Pfam)
- PF00254 FKBP_C
- InterPro
- FKBP-type_PPIase, PPIase_dom_sf, PPIase_FKBP_dom
- Functional cluster
- Toxins & Defense Peptides
Experimental structures · PDB · 103
- 1A7X X-ray 2.00A
- 1B6C X-ray 2.60A
- 1BKF X-ray 1.60A
- 1BL4 X-ray 1.90A
- 1D6O X-ray 1.85A
- 1D7H X-ray 1.90A
- 1D7I X-ray 1.90A
- 1D7J X-ray 1.85A
- 1EYM X-ray 2.00A
- 1F40 NMR
- 1FAP X-ray 2.70A
- 1FKB X-ray 1.70A
- … and 91 more
A predicted model is available from AlphaFold.
Gene Ontology · 37
- GO:0005737 cytoplasm
- GO:0098562 cytoplasmic side of membrane
- GO:0005829 cytosol
- GO:0016020 membrane
- GO:1990425 ryanodine receptor complex
- GO:0016529 sarcoplasmic reticulum
- GO:0033017 sarcoplasmic reticulum membrane
- GO:0014802 terminal cisterna
- GO:0030018 Z disc
- GO:0070697 activin receptor binding
- GO:0005246 calcium channel regulator activity
- GO:0005528 FK506 binding
- GO:0070411 I-SMAD binding
- GO:0005527 macrolide binding
- GO:0003755 peptidyl-prolyl cis-trans isomerase activity
- GO:0030547 signaling receptor inhibitor activity
- GO:0005160 transforming growth factor beta receptor binding
- GO:0044325 transmembrane transporter binding
- GO:0034713 type I transforming growth factor beta receptor binding
- GO:0006458 'de novo' protein folding
- GO:1990000 amyloid fibril formation
- GO:0003007 heart morphogenesis
- GO:0060347 heart trabecula formation
- GO:0032926 negative regulation of activin receptor signaling pathway
- GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
- GO:0043123 positive regulation of canonical NF-kappaB signal transduction
- GO:0006457 protein folding
- GO:0051604 protein maturation
- GO:0042026 protein refolding
- GO:1902991 regulation of amyloid precursor protein catabolic process
- GO:0010881 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
- GO:0050776 regulation of immune response
- GO:0032880 regulation of protein localization
- GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion
- GO:0097435 supramolecular fiber organization
- GO:0042110 T cell activation
- GO:0055010 ventricular cardiac muscle tissue morphogenesis
Drugs targeting this protein · 6
- PIMECROLIMUS inhibitor
- TEMSIROLIMUS inhibitor
- EVEROLIMUS inhibitor
- ZOTAROLIMUS inhibitor
- TACROLIMUS inhibitor
- SIROLIMUS inhibitor
Related proteins · sequence + function similarity
- Peptidyl-prolyl cis-trans isomerase FKBP1A 0.99
- Peptidyl-prolyl cis-trans isomerase FKBP1A 0.99
- Peptidyl-prolyl cis-trans isomerase FKBP1A 0.99
- Peptidyl-prolyl cis-trans isomerase FKBP1C 0.98
- Peptidyl-prolyl cis-trans isomerase FKBP1A 0.97
- Peptidyl-prolyl cis-trans isomerase FKBP1B 0.96
- Peptidyl-prolyl cis-trans isomerase FKBP1B 0.96
- Peptidyl-prolyl cis-trans isomerase FKBP1B 0.96
- Peptidyl-prolyl cis-trans isomerase FKBP1B 0.96
- Peptidyl-prolyl cis-trans isomerase Fkbp12 0.95
- Peptidyl-prolyl cis-trans isomerase FKBP1B 0.95
- Peptidyl-prolyl cis-trans isomerase 0.91
Co-cited proteins · studied together in the literature
- Peptidyl-prolyl cis-trans isomerase FKBP1A 2 shared papers
- Ryanodine receptor 3 1 shared papers
- Ryanodine receptor 3 1 shared papers
- TGF-beta receptor type-1 2 shared papers
- Activin receptor type-1B 1 shared papers
- Peptidyl-prolyl cis-trans isomerase FKBP4 1 shared papers
- Glomulin 1 shared papers
- FK506-binding protein 1 1 shared papers
Literature · 23 cited papers
- Characterization of the binding sites for the interactions between FKBP12 and intracellular calcium release channels. Arch. Biochem. Biophys. · 2012
- Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
- FKBP12 functions as an adaptor of the Smad7-Smurf1 complex on activin type I receptor. J. Mol. Endocrinol. · 2006
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
- Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. Nat. Biotechnol. · 2003
- The DNA sequence and comparative analysis of human chromosome 20. Nature · 2001
- X-ray structures of small ligand-FKBP complexes provide an estimate for hydrophobic interaction energies. J. Mol. Biol. · 2000
- Further characterization of the type 3 ryanodine receptor (RyR3) purified from rabbit diaphragm. J. Biol. Chem. · 1999
- Crystal structure of the cytoplasmic domain of the type I TGF beta receptor in complex with FKBP12. Cell · 1999
- Mechanism of TGFbeta receptor inhibition by FKBP12. EMBO J. · 1997
- FAP48, a new protein that forms specific complexes with both immunophilins FKBP59 and FKBP12. Prevention by the immunosuppressant drugs FK506 and rapamycin. J. Biol. Chem. · 1996
- 1H, 13C, and 15N assignments and secondary structure of the FK506 binding protein when bound to ascomycin. Biopolymers · 1993
- … and 11 more in the literature graph
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