Ribosomal protein S6 kinase alpha-2

Function

Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of transcription factors, regulates translation, and mediates cellular proliferation, survival, and differentiation. May function as tumor suppressor in epithelial ovarian cancer cells.

Classification

Family (Pfam)

PF00069 Pkinase, PF00433 Pkinase_C

InterPro

AGC-kinase_C, Kinase-like_dom_sf, Pkinase_C, Prot_kinase_dom, Protein_kinase_ATP_BS, Ribosomal_S6_kinase_II, RSK3_STKc, RSK_N, Ser/Thr_kinase_AS

Functional cluster

Serine/Threonine Protein Kinases

Gene Ontology · 19

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0072687 meiotic spindle
• GO:0005654 nucleoplasm
• GO:0005634 nucleus
• GO:0045202 synapse
• GO:0005524 ATP binding
• GO:0000287 magnesium ion binding
• GO:0106310 protein serine kinase activity
• GO:0004674 protein serine/threonine kinase activity
• GO:0004712 protein serine/threonine/tyrosine kinase activity
• GO:0004711 ribosomal protein S6 kinase activity
• GO:0007268 chemical synaptic transmission
• GO:0035556 intracellular signal transduction
• GO:0045786 negative regulation of cell cycle
• GO:0008285 negative regulation of cell population proliferation
• GO:0043065 positive regulation of apoptotic process
• GO:0007165 signal transduction
• GO:0038202 TORC1 signaling

Drugs targeting this protein · 1

• TAS0612 inhibitor

Related proteins · sequence + function similarity

• Ribosomal protein S6 kinase alpha-2 0.99
• Ribosomal protein S6 kinase 2 alpha 0.97
• Ribosomal protein S6 kinase alpha-3 0.96
• Ribosomal protein S6 kinase alpha-3 0.96
• Ribosomal protein S6 kinase alpha-6 0.95
• Ribosomal protein S6 kinase alpha-1 0.95
• Ribosomal protein S6 kinase alpha-6 0.95
• Ribosomal protein S6 kinase 2 beta 0.95
• Putative ribosomal protein S6 kinase alpha-1 0.94
• Ribosomal protein S6 kinase alpha-1 0.94
• Ribosomal protein S6 kinase alpha-1 0.94
• Ribosomal protein S6 kinase alpha-6 0.94

Co-cited proteins · studied together in the literature

• Ribosomal protein S6 kinase alpha-3 2 shared papers
• Ribosomal protein S6 kinase alpha-6 1 shared papers
• Ribosomal protein S6 kinase alpha-1 2 shared papers
• Ribosomal protein S6 kinase alpha-1 1 shared papers
• Ribosomal protein S6 kinase alpha-3 1 shared papers
• 3-phosphoinositide-dependent protein kinase 1 1 shared papers

Literature · 11 cited papers

• Large-scale proteomics analysis of the human kinome. Mol. Cell. Proteomics · 2009
• The RSK family of kinases: emerging roles in cellular signalling. Nat. Rev. Mol. Cell Biol. · 2008
• Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. Mol. Cell · 2008
• Patterns of somatic mutation in human cancer genomes. Nature · 2007
• RPS6KA2, a putative tumour suppressor gene at 6q27 in sporadic epithelial ovarian cancer. Oncogene · 2007
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004
• The DNA sequence and analysis of human chromosome 6. Nature · 2003
• 90-kDa ribosomal S6 kinase is phosphorylated and activated by 3-phosphoinositide-dependent protein kinase-1. J. Biol. Chem. · 1999
• Human rsk isoforms: cloning and characterization of tissue-specific expression. Am. J. Physiol. · 1994
• RSK3 encodes a novel pp90rsk isoform with a unique N-terminal sequence: growth factor-stimulated kinase function and nuclear translocation. Mol. Cell. Biol. · 1995