Ribosomal protein S6 kinase alpha-6

Function

Constitutively active serine/threonine-protein kinase that exhibits growth-factor-independent kinase activity and that may participate in p53/TP53-dependent cell growth arrest signaling and play an inhibitory role during embryogenesis.

Classification

Family (Pfam)

PF00069 Pkinase, PF00433 Pkinase_C

InterPro

AGC-kinase_C, Kinase-like_dom_sf, Pkinase_C, Prot_kinase_dom, Protein_kinase_ATP_BS, Ribosomal_S6_kinase_II, RSK_N, Ser/Thr_kinase_AS

Functional cluster

Serine/Threonine Protein Kinases

Experimental structures · PDB · 3

• 6G76 X-ray 3.00A
• 6G77 X-ray 2.50A
• 6G78 X-ray 2.50A

A predicted model is available from AlphaFold.

Gene Ontology · 15

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005654 nucleoplasm
• GO:0005524 ATP binding
• GO:0000287 magnesium ion binding
• GO:0004672 protein kinase activity
• GO:0106310 protein serine kinase activity
• GO:0004711 ribosomal protein S6 kinase activity
• GO:0007417 central nervous system development
• GO:0030330 DNA damage response, signal transduction by p53 class mediator
• GO:0045992 negative regulation of embryonic development
• GO:0070373 negative regulation of ERK1 and ERK2 cascade
• GO:2000381 negative regulation of mesoderm development
• GO:0007165 signal transduction
• GO:0038202 TORC1 signaling

Drugs targeting this protein · 1

• TAS0612 inhibitor

Related proteins · sequence + function similarity

• Ribosomal protein S6 kinase alpha-6 0.97
• Ribosomal protein S6 kinase alpha-3 0.97
• Ribosomal protein S6 kinase alpha-3 0.97
• Ribosomal protein S6 kinase alpha-6 0.96
• Ribosomal protein S6 kinase 2 alpha 0.96
• Ribosomal protein S6 kinase alpha-2 0.96
• Ribosomal protein S6 kinase 2 alpha 0.95
• Ribosomal protein S6 kinase alpha-2 0.95
• Putative ribosomal protein S6 kinase alpha-1 0.95
• Ribosomal protein S6 kinase alpha-1 0.94
• Ribosomal protein S6 kinase alpha-1 0.94
• Ribosomal protein S6 kinase alpha-1 0.94

Co-cited proteins · studied together in the literature

• Ribosomal protein S6 kinase alpha-2 1 shared papers
• Histone acetyltransferase KAT5 1 shared papers
• Ribosomal protein S6 kinase alpha-3 1 shared papers
• Ribosomal protein S6 kinase alpha-1 1 shared papers

Literature · 9 cited papers

• System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. Sci. Signal. · 2011
• The RSK family of kinases: emerging roles in cellular signalling. Nat. Rev. Mol. Cell Biol. · 2008
• Patterns of somatic mutation in human cancer genomes. Nature · 2007
• The DNA sequence of the human X chromosome. Nature · 2005
• Functional characterization of human RSK4, a new 90-kDa ribosomal S6 kinase, reveals constitutive activation in most cell types. J. Biol. Chem. · 2005
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• A large-scale RNAi screen in human cells identifies new components of the p53 pathway. Nature · 2004
• Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004
• A novel ribosomal S6-kinase (RSK4; RPS6KA6) is commonly deleted in patients with complex X-linked mental retardation. Genomics · 1999