Cyclin-dependent kinase 10

Function

Cyclin-dependent kinase that phosphorylates the transcription factor ETS2 (in vitro) and positively controls its proteasomal degradation (in cells). Involved in the regulation of actin cytoskeleton organization through the phosphorylation of actin dynamics regulators such as PKN2. Is a negative regulator of ciliogenesis through phosphorylation of PKN2 and promotion of RhoA signaling.

Classification

Family (Pfam)

PF00069 Pkinase

InterPro

CDK, Kinase-like_dom_sf, Prot_kinase_dom, Protein_kinase_ATP_BS, Ser/Thr_kinase_AS, STKc_CDK10

Functional cluster

Serine/Threonine Protein Kinases

Gene Ontology · 14

• GO:0036064 ciliary basal body
• GO:0005634 nucleus
• GO:0005524 ATP binding
• GO:0004693 cyclin-dependent protein serine/threonine kinase activity
• GO:0106310 protein serine kinase activity
• GO:0004674 protein serine/threonine kinase activity
• GO:0030030 cell projection organization
• GO:0000086 G2/M transition of mitotic cell cycle
• GO:0008285 negative regulation of cell population proliferation
• GO:1902018 negative regulation of cilium assembly
• GO:0018107 peptidyl-threonine phosphorylation
• GO:0032956 regulation of actin cytoskeleton organization
• GO:1902749 regulation of cell cycle G2/M phase transition
• GO:0007089 traversing start control point of mitotic cell cycle

Disease associations

• Al Kaissi syndrome MONDO:0044324

Drugs targeting this protein · 4

• PHA-793887 inhibitor
• RONICICLIB inhibitor
• AT-7519 inhibitor
• AZD-5438 inhibitor

Related proteins · sequence + function similarity

• Cyclin-dependent kinase 10 1.00
• Cyclin-dependent kinase 10 0.99
• Cyclin-dependent kinase 10 0.98
• Cyclin-dependent kinase 3 0.89
• Cyclin-dependent kinase 2 0.89
• Cyclin-dependent kinase 2 0.89
• Cyclin-dependent kinase 2 0.89
• Cyclin-dependent kinase 2 0.88
• Cyclin-dependent kinase 3 0.88
• Cyclin-dependent kinase 2 0.88
• Cyclin-dependent kinase 2 0.88
• Cyclin-dependent kinase 7 0.88

Co-cited proteins · studied together in the literature

• Cyclin-dependent kinase 10 1 shared papers
• Cyclin-Q 1 shared papers
• Protein C-ets-2 1 shared papers
• Serine/threonine-protein kinase N2 1 shared papers

Literature · 12 cited papers

• CDK10 mutations in humans and mice cause severe growth retardation, spine malformations, and developmental delays. Am. J. Hum. Genet. · 2017
• STAR syndrome-associated CDK10/Cyclin M regulates actin network architecture and ciliogenesis. Cell Cycle · 2016
• CDK10/cyclin M is a protein kinase that controls ETS2 degradation and is deficient in STAR syndrome. Proc. Natl. Acad. Sci. U.S.A. · 2013
• Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. Mol. Cell · 2008
• A quantitative atlas of mitotic phosphorylation. Proc. Natl. Acad. Sci. U.S.A. · 2008
• Patterns of somatic mutation in human cancer genomes. Nature · 2007
• The sequence and analysis of duplication-rich human chromosome 16. Nature · 2004
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004
• The PISSLRE gene: structure, exon skipping, and exclusion as tumor suppressor in breast cancer. Genomics · 1999
• PISSLRE, a human novel CDC2-related protein kinase. Oncogene · 1994
• Molecular cloning of PISSLRE, a novel putative member of the cdk family of protein serine/threonine kinases. Oncogene · 1994