P2Y purinoceptor 6
Also known as: P2RY6
Function
Receptor for extracellular UDP > UTP > ATP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.
Classification
- Family (Pfam)
- PF00001 7tm_1
- InterPro
- GPCR_Rhodpsn, GPCR_Rhodpsn_7TM, P2Y6_rcpt
- Functional cluster
- G Protein-Coupled Receptors
Gene Ontology · 14
- GO:0005886 plasma membrane
- GO:0001621 G protein-coupled ADP receptor activity
- GO:0004930 G protein-coupled receptor activity
- GO:0045029 G protein-coupled UDP receptor activity
- GO:0045030 G protein-coupled UTP receptor activity
- GO:0071415 cellular response to purine-containing compound
- GO:1905835 cellular response to pyrimidine ribonucleotide
- GO:0007186 G protein-coupled receptor signaling pathway
- GO:0006909 phagocytosis
- GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway
- GO:0070374 positive regulation of ERK1 and ERK2 cascade
- GO:0032962 positive regulation of inositol trisphosphate biosynthetic process
- GO:0051281 positive regulation of release of sequestered calcium ion into cytosol
- GO:1904707 positive regulation of vascular associated smooth muscle cell proliferation
Drugs targeting this protein · 1
- DIQUAFOSOL TETRASODIUM agonist
Related proteins · sequence + function similarity
- P2Y purinoceptor 6 0.99
- P2Y purinoceptor 6 0.99
- P2Y purinoceptor 2 0.94
- P2Y purinoceptor 4 0.94
- P2Y purinoceptor 2 0.93
- P2Y purinoceptor 4 0.93
- P2Y purinoceptor 2 0.93
- P2Y purinoceptor 4 0.93
- P2Y purinoceptor 2 0.93
- P2Y purinoceptor 3 0.92
- P2Y purinoceptor 3 0.91
- S-geranylgeranyl-glutathione receptor P2RY8 0.91
Literature · 6 cited papers
- Large-scale cDNA transfection screening for genes related to cancer development and progression. Proc. Natl. Acad. Sci. U.S.A. · 2004
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
- PMID 9412455 Biochem. Biophys. Res. Commun. · 1997
- Chromosomal localization of the human P2y6 purinoceptor gene and phylogenetic analysis of the P2y purinoceptor family. Genomics · 1997
- Cloning of P2Y6 cDNAs and identification of a pseudogene: comparison of P2Y receptor subtype expression in bone and brain tissues. Biochem. Biophys. Res. Commun. · 1997
- Cloning, functional expression and tissue distribution of the human P2Y6 receptor. Biochem. Biophys. Res. Commun. · 1996
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