P2Y purinoceptor 4
Also known as: NRU, P2RY4
Function
Receptor for UTP and UDP coupled to G proteins that activate a phosphatidylinositol-calcium second messenger system. Not activated by ATP or ADP.
Classification
- Family (Pfam)
- PF00001 7tm_1
- InterPro
- GPCR_Rhodpsn, GPCR_Rhodpsn_7TM, P2Y4
- Functional cluster
- G Protein-Coupled Receptors
Experimental structures · PDB · 1
- 9K0K EM 3.14A
A predicted model is available from AlphaFold.
Gene Ontology · 8
- GO:0005886 plasma membrane
- GO:0045028 G protein-coupled purinergic nucleotide receptor activity
- GO:0045030 G protein-coupled UTP receptor activity
- GO:0071318 cellular response to ATP
- GO:0007186 G protein-coupled receptor signaling pathway
- GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway
- GO:0007204 positive regulation of cytosolic calcium ion concentration
- GO:0030321 transepithelial chloride transport
Drugs targeting this protein · 1
- DIQUAFOSOL TETRASODIUM agonist
Related proteins · sequence + function similarity
- P2Y purinoceptor 4 0.99
- P2Y purinoceptor 4 0.98
- P2Y purinoceptor 2 0.97
- P2Y purinoceptor 2 0.97
- P2Y purinoceptor 2 0.96
- P2Y purinoceptor 2 0.96
- P2Y purinoceptor 6 0.94
- P2Y purinoceptor 6 0.94
- P2Y purinoceptor 6 0.94
- S-geranylgeranyl-glutathione receptor P2RY8 0.92
- P2Y purinoceptor 4 0.92
- Proteinase-activated receptor 4 0.90
Literature · 6 cited papers
- The DNA sequence of the human X chromosome. Nature · 2005
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
- Differential regulation of the uridine nucleotide-activated P2Y4 and P2Y6 receptors. Ser-333 and Ser-334 in the carboxyl terminus are involved in agonist-dependent phosphorylation desensitization and internalization of the P2Y4 receptor. J. Biol. Chem. · 2001
- Molecular cloning and characterization of a novel orphan receptor (P2P) expressed in human pancreas that shows high structural homology to the P2U purinoceptor. FEBS Lett. · 1996
- Cloning and functional expression of a human uridine nucleotide receptor. J. Biol. Chem. · 1995
- Cloning, expression, and chromosomal localization of the human uridine nucleotide receptor gene. J. Biol. Chem. · 1995
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