P2Y purinoceptor 2
Also known as: P2RU1, P2RY2
Function
Receptor for ATP and UTP coupled to G proteins that activate a phosphatidylinositol-calcium second messenger system. The affinity range is UTP = ATP > ATP-gamma-S >> 2-methylthio-ATP = ADP.
Classification
- Family (Pfam)
- PF00001 7tm_1
- InterPro
- GPCR_Rhodpsn, GPCR_Rhodpsn_7TM, P2Y2_rcpt
- Functional cluster
- G Protein-Coupled Receptors
Experimental structures · PDB · 3
A predicted model is available from AlphaFold.
Gene Ontology · 12
- GO:0005886 plasma membrane
- GO:0031686 A1 adenosine receptor binding
- GO:0045028 G protein-coupled purinergic nucleotide receptor activity
- GO:0045030 G protein-coupled UTP receptor activity
- GO:0038023 signaling receptor activity
- GO:0097746 blood vessel diameter maintenance
- GO:0071318 cellular response to ATP
- GO:0035589 G protein-coupled purinergic nucleotide receptor signaling pathway
- GO:0007186 G protein-coupled receptor signaling pathway
- GO:0006873 intracellular monoatomic ion homeostasis
- GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway
- GO:0070257 positive regulation of mucus secretion
Drugs targeting this protein · 2
- DENUFOSOL TETRASODIUM agonist
- DIQUAFOSOL TETRASODIUM agonist
Related proteins · sequence + function similarity
- P2Y purinoceptor 2 0.99
- P2Y purinoceptor 2 0.99
- P2Y purinoceptor 2 0.98
- P2Y purinoceptor 4 0.96
- P2Y purinoceptor 4 0.95
- P2Y purinoceptor 4 0.94
- P2Y purinoceptor 6 0.94
- P2Y purinoceptor 6 0.93
- P2Y purinoceptor 6 0.93
- S-geranylgeranyl-glutathione receptor P2RY8 0.90
- P2Y purinoceptor 4 0.89
- Lysophosphatidic acid receptor 5 0.88
Literature · 5 cited papers
- Human chromosome 11 DNA sequence and analysis including novel gene identification. Nature · 2006
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
- Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004
- Cloning and expression of a human P2U nucleotide receptor, a target for cystic fibrosis pharmacotherapy. Proc. Natl. Acad. Sci. U.S.A. · 1994
- Cloning and expression of a human P2U nucleotide receptor, a target for cystic fibrosis pharmacotherapy. Proc. Natl. Acad. Sci. U.S.A. · 1994
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