lmmol · Proteins

DNA polymerase alpha subunit B

UniProt Q14181 Organism Homo sapiens Gene POLA2

Also known as: POLA2

Function

Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit POLA1, an accessory subunit POLA2 and two primase subunits, the catalytic subunit PRIM1 and the regulatory subunit PRIM2) is recruited to DNA at the replicative forks via direct interactions with MCM10 and WDHD1 (By similarity). The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands (By similarity). These primers are initially extended by the polymerase alpha catalytic subunit and subsequently transferred to polymerase delta and polymerase epsilon for processive synthesis on the lagging and leading strand, respectively (By similarity).

Classification

Family (Pfam)
PF04042 DNA_pol_E_B, PF22062 OB_DPOA2, PF08418 Pol_alpha_B_N
InterPro
DNA_pol_a/d/e_bsu, DNA_pol_alpha_B_N_sf, DNA_pol_alpha_bsu, OB_DPOA2, Pol_alpha_B_N
Functional cluster
Zinc-Finger & Chromatin Regulatory Proteins

Experimental structures · PDB · 13

A predicted model is available from AlphaFold.

Gene Ontology · 6

Drugs targeting this protein · 6

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Literature · 14 cited papers

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