Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma
Also known as: PDE6H
Function
Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones.
Classification
- Family (Pfam)
- PF04868 PDE6_gamma
- InterPro
- PDE6_gamma, PDE6_gamma_sf
- Functional cluster
- Adenylate Kinases & Peroxiredoxins
Gene Ontology · 7
- GO:0042622 photoreceptor outer segment membrane
- GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity
- GO:0030553 cGMP binding
- GO:0004857 enzyme inhibitor activity
- GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway
- GO:0045745 positive regulation of G protein-coupled receptor signaling pathway
- GO:0007601 visual perception
Disease associations
- achromatopsia 6 MONDO:0012398
Drugs targeting this protein · 2
- PENTOXIFYLLINE inhibitor
- DIPYRIDAMOLE inhibitor
Related proteins · sequence + function similarity
- Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma 0.98
- Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma 0.95
- Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma 0.93
- Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma 0.91
- Rod cGMP 3',5'-cyclic phosphodiesterase subunit gamma 0.76
- Rod cGMP 3',5'-cyclic phosphodiesterase subunit gamma 0.69
- Rod cGMP 3',5'-cyclic phosphodiesterase subunit gamma 0.65
- Rod cGMP 3',5'-cyclic phosphodiesterase subunit gamma 0.65
- Nucleoprotein 0.62
- Rod cGMP 3',5'-cyclic phosphodiesterase subunit gamma 0.62
- Nucleoprotein 0.61
- Nucleoprotein 0.61
Literature · 3 cited papers
- A substitution of G to C in the cone cGMP-phosphodiesterase gamma subunit gene found in a distinctive form of cone dystrophy. Ophthalmology · 2005
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
- Isolation and chromosomal localization of the human cone cGMP phosphodiesterase gamma cDNA (PDE6H). Genomics · 1996
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