Rod cGMP 3',5'-cyclic phosphodiesterase subunit gamma

Function

Inhibitory gamma subunit of the rod-specific cGMP phosphodiesterase (PDE6) complex, which hydrolyzes 3',5'-cyclic GMP in the phototransduction cascade. The PDE6 holoenzyme consists of two catalytic subunits (PDE6A and PDE6B) and two inhibitory gamma subunits. Light-activated GNAT1 relieves gamma subunit-mediated inhibition, enabling the catalytic subunits to hydrolyze cGMP and thereby mediate visual signal transduction and amplification.

Classification

Family (Pfam)

PF04868 PDE6_gamma

InterPro

PDE6_gamma, PDE6_gamma_sf

Functional cluster

Amino-Acid & Central Metabolism Enzymes

Experimental structures · PDB · 1

• 3JWR X-ray 2.99A

A predicted model is available from AlphaFold.

Gene Ontology · 11

• GO:0097381 photoreceptor disc membrane
• GO:0001750 photoreceptor outer segment
• GO:0042622 photoreceptor outer segment membrane
• GO:0005886 plasma membrane
• GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity
• GO:0030553 cGMP binding
• GO:0004857 enzyme inhibitor activity
• GO:0030507 spectrin binding
• GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway
• GO:0045745 positive regulation of G protein-coupled receptor signaling pathway
• GO:0007601 visual perception

Disease associations

• retinitis pigmentosa 57 MONDO:0013315

Drugs targeting this protein · 2

• PENTOXIFYLLINE inhibitor
• DIPYRIDAMOLE inhibitor

Related proteins · sequence + function similarity

• Rod cGMP 3',5'-cyclic phosphodiesterase subunit gamma 0.98
• Rod cGMP 3',5'-cyclic phosphodiesterase subunit gamma 0.98
• Rod cGMP 3',5'-cyclic phosphodiesterase subunit gamma 0.97
• Rod cGMP 3',5'-cyclic phosphodiesterase subunit gamma 0.95
• Rod cGMP 3',5'-cyclic phosphodiesterase subunit gamma 0.87
• Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma 0.77
• Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma 0.77
• Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma 0.72
• Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma 0.69
• Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma 0.64
• Uncharacterized protein DDB_G0280919 0.62
• Diptericin 0.59

Literature · 6 cited papers

• Autosomal-recessive early-onset retinitis pigmentosa caused by a mutation in PDE6G, the gene encoding the gamma subunit of rod cGMP phosphodiesterase. Am. J. Hum. Genet. · 2010
• The full-ORF clone resource of the German cDNA consortium. BMC Genomics · 2007
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• Evaluation of the gene encoding the gamma subunit of rod phosphodiesterase in retinitis pigmentosa. Invest. Ophthalmol. Vis. Sci. · 1994
• Isolation and characterization of cDNA encoding the gamma-subunit of cGMP phosphodiesterase in human retina. Gene · 1990
• The organization of the gamma-subunit gene of human photoreceptor cyclic GMP phosphodiesterase. Dokl. Akad. Nauk SSSR · 1990