lmmol · Proteins

Rho-associated protein kinase 1

UniProt Q13464 Organism Homo sapiens Gene ROCK1 EC 2.7.11.39

Also known as: ROCK1

Function

Protein kinase which is a key regulator of the actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, TPPP, PFN1 and PPP1R12A. Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing. Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress. Acts as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability (By similarity). Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Required for centrosome positioning and centrosome-dependent exit from mitosis (By similarity). Plays a role in terminal erythroid differentiation. Inhibits podocyte motility via regulation of actin cytoskeletal dynamics and phosphorylation of CFL1 (By similarity). Promotes keratinocyte terminal differentiation. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization (By similarity). May regulate closure of the eyelids and ventral body wall by inducing the assembly of actomyosin bundles (By similarity).

Classification

Family (Pfam)
PF25346 PH_MRCK, PF00069 Pkinase, PF08912 Rho_Binding
InterPro
AGC-kinase_C, C1-like_sf, HR1_rho-bd, Kinase-like_dom_sf, MRCK/ROCK_PH, PH-like_dom_sf, PH_domain, PKC_DAG/PE, Prot_kinase_dom, Protein_kinase_ATP_BS, Rho-assoc_Ser/Thr_Kinase, ROCK1/ROCK2, ROCK1_HR1, ROCK_Rho-bd_dom, Ser/Thr_kinase_AS
Functional cluster
Protein Serine/Threonine Kinases

Experimental structures · PDB · 32

A predicted model is available from AlphaFold.

Gene Ontology · 76

Drugs targeting this protein · 9

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Literature · 38 cited papers

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