lmmol · Proteins

Rho-associated protein kinase 2

UniProt O75116 Organism Homo sapiens Gene KIAA0619, ROCK2 EC 2.7.11.39

Also known as: KIAA0619, ROCK2

Function

Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of ADD1, BRCA2, CNN1, EZR, DPYSL2, EP300, MSN, MYL9/MLC2, NPM1, RDX, PPP1R12A and VIM. Phosphorylates SORL1 and IRF4. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Positively regulates the activation of p42/MAPK1-p44/MAPK3 and of p90RSK/RPS6KA1 during myogenic differentiation. Plays an important role in the timely initiation of centrosome duplication. Inhibits keratinocyte terminal differentiation. May regulate closure of the eyelids and ventral body wall through organization of actomyosin bundles. Plays a critical role in the regulation of spine and synaptic properties in the hippocampus. Plays an important role in generating the circadian rhythm of the aortic myofilament Ca(2+) sensitivity and vascular contractility by modulating the myosin light chain phosphorylation.

Classification

Family (Pfam)
PF25346 PH_MRCK, PF00069 Pkinase, PF08912 Rho_Binding
InterPro
AGC-kinase_C, C1-like_sf, HR1_rho-bd, Kinase-like_dom_sf, MRCK/ROCK_PH, PH-like_dom_sf, PH_domain, PKC_DAG/PE, Prot_kinase_dom, Protein_kinase_ATP_BS, Rho-assoc_Ser/Thr_Kinase, ROCK1/ROCK2, ROCK2_cat, ROCK2_HR1, ROCK_Rho-bd_dom, Ser/Thr_kinase_AS
Functional cluster
ATP Synthase Gamma Subunit & related

Experimental structures · PDB · 21

A predicted model is available from AlphaFold.

Gene Ontology · 70

Drugs targeting this protein · 10

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Literature · 27 cited papers

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