Protein phosphatase 1 regulatory subunit 12A

UniProt O14974 Organism Homo sapiens Gene MBS, MYPT1, PPP1R12A

Also known as: MBS, MYPT1, PPP1R12A

Function

Key regulator of protein phosphatase 1C (PPP1C). Mediates binding to myosin. As part of the PPP1C complex, involved in dephosphorylation of PLK1. Capable of inhibiting HIF1AN-dependent suppression of HIF1A activity.

Classification

Family (Pfam): PF12796 Ank_2, PF15898 PRKG1_interact
InterPro: Ankyrin_rpt, Ankyrin_rpt-contain_sf, MYPT1/MYPT2/Mbs85, PP1_Regulatory_Subunit, PRKG1_interact
Functional cluster: RRM RNA-Binding & Protein Kinases

Experimental structures · PDB · 2

2KJY NMR
5HUZ NMR

A predicted model is available from AlphaFold.

Gene Ontology · 25

Disease associations

genitourinary and/or brain malformation syndrome MONDO:0032934

Neighborhood · nearest proteins

Nearest neighbours of Protein phosphatase 1 regulatory subunit 12A: 3 by sequence/function similarity (left); 3 co-cited in the literature (right).

Related proteins · sequence + function similarity

Protein phosphatase 1 regulatory subunit 12A 0.99
Protein phosphatase 1 regulatory subunit 12A 0.99
Protein phosphatase 1 regulatory subunit 12A 0.98
Protein phosphatase 1 regulatory subunit 12A 0.96
Protein phosphatase 1 regulatory subunit 12B 0.82
Protein phosphatase 1 regulatory subunit 12B 0.80
Cytospin-A 0.69
Cytospin-A 0.68
Neuron navigator 3 0.67
Cytospin-A 0.67
Cytospin-A 0.67
Cytospin-A 0.67

Co-cited proteins · studied together in the literature

cGMP-dependent protein kinase 1 4 shared papers
Protein phosphatase 1 regulatory subunit 12A 3 shared papers
Protein phosphatase 1 regulatory subunit 12B 2 shared papers
Rho-related GTP-binding protein RhoE 1 shared papers
Rho-associated protein kinase 1 4 shared papers
Serine/threonine-protein kinase MRCK alpha 2 shared papers
Myosin regulatory light chain 12B 1 shared papers
Hypoxia-inducible factor 1-alpha inhibitor 1 shared papers
Protein phosphatase 1 regulatory subunit 12A 1 shared papers
Pro-interleukin-16 1 shared papers
Smoothelin-like protein 1 1 shared papers
Smoothelin-like protein 1 1 shared papers

Literature · 42 cited papers

Loss-of-function variants in PPP1R12A: from isolated sex reversal to holoprosencephaly spectrum and urogenital malformations. Am. J. Hum. Genet. · 2020
An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J. Proteomics · 2014
Toward a comprehensive characterization of a human cancer cell phosphoproteome. J. Proteome Res. · 2013
N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. Proc. Natl. Acad. Sci. U.S.A. · 2012
Chelerythrine perturbs lamellar actomyosin filaments by selective inhibition of myotonic dystrophy kinase-related Cdc42-binding kinase. FEBS Lett. · 2011
System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. Sci. Signal. · 2011
Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
Smoothelin-like 1 protein regulates myosin phosphatase-targeting subunit 1 expression during sexual development and pregnancy. J. Biol. Chem. · 2010
New roles for the LKB1-NUAK pathway in controlling myosin phosphatase complexes and cell adhesion. Sci. Signal. · 2010
Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. Sci. Signal. · 2010
Distinct roles for ROCK1 and ROCK2 in the regulation of keratinocyte differentiation. PLoS ONE · 2009
Solution structure of the inhibitory phosphorylation domain of myosin phosphatase targeting subunit 1. Proteins · 2009
… and 30 more in the literature graph

A document in the lmmol reference corpus — open public data (UniProt, GO, PDB, the literature graph) rendered as a single cross-linked page. Hover any link to preview its target.