Voltage-dependent L-type calcium channel subunit beta-2

UniProt Q08289 Organism Homo sapiens Gene CACNB2, CACNLB2, MYSB

Also known as: CACNB2, CACNLB2, MYSB

Function

Beta subunit of voltage-dependent calcium channels which contributes to the function of the calcium channel by increasing peak calcium current (By similarity). Plays a role in shifting voltage dependencies of activation and inactivation of the channel (By similarity). May modulate G protein inhibition (By similarity). May contribute to beta-adrenergic augmentation of Ca(2+) influx in cardiomyocytes, thereby regulating increases in heart rate and contractile force. Involved in membrane targeting of the alpha-1 subunit CACNA1C.

Classification

Family (Pfam): PF00625 Guanylate_kin, PF12052 VGCC_beta4Aa_N
InterPro: CAB1-4_N_A-dom, CACNB2_SH3, GK/Ca_channel_bsu, P-loop_NTPase, SH3-like_dom_sf, SH3_domain, VDCC_L_b2su, VDCC_L_bsu
Functional cluster: RNA-Polymerase II Transcription Factors

Experimental structures · PDB · 3

8HLP EM 3.50A
8HMA EM 3.40A
8HMB EM 3.30A

A predicted model is available from AlphaFold.

Gene Ontology · 22

Disease associations

Brugada syndrome 4 MONDO:0012743

Drugs targeting this protein · 9

PREGABALIN modulator
BEPRIDIL HYDROCHLORIDE blocker
GABAPENTIN ENACARBIL modulator
IMAGABALIN modulator
SULOCTIDIL blocker
PHLOROGLUCINOL blocker
TERODILINE HYDROCHLORIDE blocker
ATAGABALIN modulator
GABAPENTIN modulator

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Voltage-dependent L-type calcium channel subunit beta-4 1 shared papers
GTP-binding protein RAD 2 shared papers
Voltage-dependent L-type calcium channel subunit beta-2 1 shared papers
Voltage-dependent L-type calcium channel subunit beta-2 1 shared papers
Voltage-dependent L-type calcium channel subunit alpha-1C 1 shared papers
Melanoma-derived growth regulatory protein 1 shared papers
Transmembrane and immunoglobulin domain-containing protein 2 1 shared papers
Voltage-dependent L-type calcium channel subunit alpha-1C 1 shared papers
NCK-interacting protein with SH3 domain 1 shared papers
Leucine-rich repeat-containing protein 7 1 shared papers
Metabotropic glutamate receptor 5 1 shared papers
Dystonin 1 shared papers

Literature · 12 cited papers

Rad regulation of CaV1.2 channels controls cardiac fight-or-flight response. Nat. Cardiovasc. Res. · 2022
Mutation Disrupts Dendritic Morphology and Synaptic Transmission, and Causes ASD-Related Behaviors. J. Neurosci. · 2017
Identification of IGPR-1 as a novel adhesion molecule involved in angiogenesis. Mol. Biol. Cell · 2012
Dominant negative suppression of Rad leads to QT prolongation and causes ventricular arrhythmias via modulation of L-type Ca2+ channels in the heart. Circ. Res. · 2007
Loss-of-function mutations in the cardiac calcium channel underlie a new clinical entity characterized by ST-segment elevation, short QT intervals, and sudden cardiac death. Circulation · 2007
The consensus coding sequences of human breast and colorectal cancers. Science · 2006
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
The DNA sequence and comparative analysis of human chromosome 10. Nature · 2004
Molecular heterogeneity of calcium channel beta-subunits in canine and human heart: evidence for differential subcellular localization. Physiol. Genomics · 2004
Novel functional properties of Ca(2+) channel beta subunits revealed by their expression in adult rat heart cells. J. Physiol. (Lond.) · 2002
Assignment of human genes for beta 2 and beta 4 subunits of voltage-dependent Ca2+ channels to chromosomes 10p12 and 2q22-q23. Hum. Genet. · 1997
Cloning and characterization of a Lambert-Eaton myasthenic syndrome antigen. Ann. Neurol. · 1993

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