Voltage-dependent L-type calcium channel subunit beta-4
Also known as: CACNB4, CACNLB4
Function
The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting.
Classification
- Family (Pfam)
- PF00625 Guanylate_kin, PF12052 VGCC_beta4Aa_N
- InterPro
- CAB1-4_N_A-dom, GK/Ca_channel_bsu, P-loop_NTPase, SH3-like_dom_sf, SH3_domain, VDCC_L_bsu
- Functional cluster
- Mixed Regulatory & Membrane Proteins
Experimental structures · PDB · 1
- 2D46 NMR
A predicted model is available from AlphaFold.
Gene Ontology · 21
- GO:0009898 cytoplasmic side of plasma membrane
- GO:0005829 cytosol
- GO:0098978 glutamatergic synapse
- GO:0016607 nuclear speck
- GO:0005886 plasma membrane
- GO:0098793 presynapse
- GO:0045202 synapse
- GO:0030315 T-tubule
- GO:0005891 voltage-gated calcium channel complex
- GO:0005246 calcium channel regulator activity
- GO:0008331 high voltage-gated calcium channel activity
- GO:0019901 protein kinase binding
- GO:0099626 voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels
- GO:0070588 calcium ion transmembrane transport
- GO:0006816 calcium ion transport
- GO:0007268 chemical synaptic transmission
- GO:0008285 negative regulation of cell population proliferation
- GO:2000134 negative regulation of G1/S transition of mitotic cell cycle
- GO:0045933 positive regulation of muscle contraction
- GO:1904751 positive regulation of protein localization to nucleolus
- GO:2000300 regulation of synaptic vesicle exocytosis
Disease associations
- epilepsy, idiopathic generalized, susceptibility to, 9 MONDO:0011892
- episodic ataxia type 5 MONDO:0013464
Drugs targeting this protein · 9
- PREGABALIN modulator
- BEPRIDIL HYDROCHLORIDE blocker
- GABAPENTIN ENACARBIL modulator
- IMAGABALIN modulator
- SULOCTIDIL blocker
- PHLOROGLUCINOL blocker
- TERODILINE HYDROCHLORIDE blocker
- ATAGABALIN modulator
- GABAPENTIN modulator
Related proteins · sequence + function similarity
- Voltage-dependent L-type calcium channel subunit beta-4 1.00
- Voltage-dependent L-type calcium channel subunit beta-4 1.00
- Voltage-dependent L-type calcium channel subunit beta-2 0.94
- Voltage-dependent L-type calcium channel subunit beta-2 0.93
- Voltage-dependent L-type calcium channel subunit beta-2 0.92
- Voltage-dependent L-type calcium channel subunit beta-2 0.92
- Voltage-dependent L-type calcium channel subunit beta-2 0.91
- Voltage-dependent L-type calcium channel subunit beta-1 0.85
- Voltage-dependent L-type calcium channel subunit beta-1 0.85
- Voltage-dependent L-type calcium channel subunit beta-1 0.84
- Voltage-dependent L-type calcium channel subunit beta-1 0.84
- Voltage-dependent L-type calcium channel subunit beta-1 0.84
Co-cited proteins · studied together in the literature
- Voltage-dependent L-type calcium channel subunit beta-2 1 shared papers
Literature · 10 cited papers
- Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening. BMC Immunol. · 2009
- The GK domain of the voltage-dependent calcium channel beta subunit is essential for binding to the alpha subunit. Biochem. Biophys. Res. Commun. · 2007
- Solution structure of the N-terminal A domain of the human voltage-gated Ca2+channel beta4a subunit. Protein Sci. · 2006
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. Nature · 2005
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
- Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004
- Alternative splicing of the beta 4 subunit has alpha 1 subunit subtype-specific effects on Ca2+ channel gating. J. Neurosci. · 2002
- Coding and noncoding variation of the human calcium-channel beta4-subunit gene CACNB4 in patients with idiopathic generalized epilepsy and episodic ataxia. Am. J. Hum. Genet. · 2000
- Calcium channel beta4 (CACNB4): human ortholog of the mouse epilepsy gene lethargic. Genomics · 1998
- Assignment of human genes for beta 2 and beta 4 subunits of voltage-dependent Ca2+ channels to chromosomes 10p12 and 2q22-q23. Hum. Genet. · 1997
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