Large ribosomal subunit protein uL24

Function

One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.

Classification

Family (Pfam)

PF00467 KOW, PF17136 ribosomal_L24

InterPro

KOW, Rib_uL2_dom2, Ribosomal_uL24, Ribosomal_uL24_C, Ribosomal_uL24_CS, Ribosomal_uL24_KOW, Translation_prot_SH3-like_sf

Functional cluster

Co-Chaperonins & Elongation Factors

Gene Ontology · 4

• GO:0022625 cytosolic large ribosomal subunit
• GO:0019843 rRNA binding
• GO:0003735 structural constituent of ribosome
• GO:0006412 translation

Drugs targeting this protein · 2

• LINCOMYCIN HYDROCHLORIDE inhibitor
• TROLEANDOMYCIN inhibitor

Related proteins · sequence + function similarity

• Large ribosomal subunit protein uL24 1.00
• Large ribosomal subunit protein uL24 1.00
• Large ribosomal subunit protein uL24 1.00
• Large ribosomal subunit protein uL24 1.00
• Large ribosomal subunit protein uL24 1.00
• Large ribosomal subunit protein uL24 1.00
• Large ribosomal subunit protein uL24 1.00
• Large ribosomal subunit protein uL24 1.00
• Large ribosomal subunit protein uL24 0.98
• Large ribosomal subunit protein uL24 0.98
• Large ribosomal subunit protein uL24 0.98
• Large ribosomal subunit protein uL24 0.98

Co-cited proteins · studied together in the literature

• Large ribosomal subunit protein uL16 1 shared papers
• Large ribosomal subunit protein uL29 1 shared papers
• Large ribosomal subunit protein uL29 1 shared papers
• Small ribosomal subunit protein uS17 1 shared papers
• Small ribosomal subunit protein uS17 1 shared papers
• Small ribosomal subunit protein uS19 1 shared papers
• Large ribosomal subunit protein uL16 1 shared papers
• Small ribosomal subunit protein uS19 1 shared papers
• Large ribosomal subunit protein uL14 1 shared papers
• Large ribosomal subunit protein uL22 1 shared papers
• Large ribosomal subunit protein uL22 1 shared papers
• Small ribosomal subunit protein uS3 1 shared papers

Literature · 2 cited papers

• Genome of the bacterium Streptococcus pneumoniae strain R6. J. Bacteriol. · 2001
• Mutations in ribosomal protein L16 conferring reduced susceptibility to evernimicin (SCH27899): implications for mechanism of action. Antimicrob. Agents Chemother. · 2000