Large ribosomal subunit protein uL16

Function

Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.

Classification

Family (Pfam)

PF00252 Ribosomal_L16

InterPro

Ribosomal_uL16, Ribosomal_uL16_bact, Ribosomal_uL16_CS, Ribosomal_uL16_dom, Ribosomal_uL16_sf

Functional cluster

Core Ribosomal Proteins (L2/L14/L16)

Gene Ontology · 5

• GO:0022625 cytosolic large ribosomal subunit
• GO:0019843 rRNA binding
• GO:0003735 structural constituent of ribosome
• GO:0000049 tRNA binding
• GO:0006412 translation

Drugs targeting this protein · 2

• LINCOMYCIN HYDROCHLORIDE inhibitor
• TROLEANDOMYCIN inhibitor

Related proteins · sequence + function similarity

• Large ribosomal subunit protein uL16 1.00
• Large ribosomal subunit protein uL16 1.00
• Large ribosomal subunit protein uL16 1.00
• Large ribosomal subunit protein uL16 1.00
• Large ribosomal subunit protein uL16 1.00
• Large ribosomal subunit protein uL16 1.00
• Large ribosomal subunit protein uL16 1.00
• Large ribosomal subunit protein uL16 1.00
• Large ribosomal subunit protein uL16 1.00
• Large ribosomal subunit protein uL16 1.00
• Large ribosomal subunit protein uL16 1.00
• Large ribosomal subunit protein uL16 1.00

Co-cited proteins · studied together in the literature

• Large ribosomal subunit protein uL16 1 shared papers
• Large ribosomal subunit protein uL29 1 shared papers
• Large ribosomal subunit protein uL29 1 shared papers
• Small ribosomal subunit protein uS17 1 shared papers
• Small ribosomal subunit protein uS17 1 shared papers
• Small ribosomal subunit protein uS19 1 shared papers
• Small ribosomal subunit protein uS19 1 shared papers
• Large ribosomal subunit protein uL14 1 shared papers
• Large ribosomal subunit protein uL22 1 shared papers
• Large ribosomal subunit protein uL22 1 shared papers
• Small ribosomal subunit protein uS3 1 shared papers
• Small ribosomal subunit protein uS3 1 shared papers

Literature · 2 cited papers

• Genome of the bacterium Streptococcus pneumoniae strain R6. J. Bacteriol. · 2001
• Mutations in ribosomal protein L16 conferring reduced susceptibility to evernimicin (SCH27899): implications for mechanism of action. Antimicrob. Agents Chemother. · 2000