Large ribosomal subunit protein uL22

Function

This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity).

Classification

Family (Pfam)

PF00237 Ribosomal_L22

InterPro

Ribosomal_uL22, Ribosomal_uL22_bac/chlpt-type, Ribosomal_uL22_bact_org, Ribosomal_uL22_CS, Ribosomal_uL22_sf

Functional cluster

Ribosomal Proteins (S5/S18, L17/L22)

Gene Ontology · 4

• GO:0022625 cytosolic large ribosomal subunit
• GO:0019843 rRNA binding
• GO:0003735 structural constituent of ribosome
• GO:0006412 translation

Drugs targeting this protein · 2

• LINCOMYCIN HYDROCHLORIDE inhibitor
• TROLEANDOMYCIN inhibitor

Related proteins · sequence + function similarity

• Large ribosomal subunit protein uL22 1.00
• Large ribosomal subunit protein uL22 1.00
• Large ribosomal subunit protein uL22 1.00
• Large ribosomal subunit protein uL22 1.00
• Large ribosomal subunit protein uL22 1.00
• Large ribosomal subunit protein uL22 1.00
• Large ribosomal subunit protein uL22 1.00
• Large ribosomal subunit protein uL22 1.00
• Large ribosomal subunit protein uL22 1.00
• Large ribosomal subunit protein uL22 0.98
• Large ribosomal subunit protein uL22 0.98
• Large ribosomal subunit protein uL22 0.98

Co-cited proteins · studied together in the literature

• Large ribosomal subunit protein uL16 1 shared papers
• Large ribosomal subunit protein uL29 1 shared papers
• Large ribosomal subunit protein uL29 1 shared papers
• Small ribosomal subunit protein uS17 1 shared papers
• Small ribosomal subunit protein uS17 1 shared papers
• Small ribosomal subunit protein uS19 1 shared papers
• Large ribosomal subunit protein uL16 1 shared papers
• Small ribosomal subunit protein uS19 1 shared papers
• Large ribosomal subunit protein uL14 1 shared papers
• Large ribosomal subunit protein uL22 1 shared papers
• Small ribosomal subunit protein uS3 1 shared papers
• Small ribosomal subunit protein uS3 1 shared papers

Literature · 2 cited papers

• Genome of the bacterium Streptococcus pneumoniae strain R6. J. Bacteriol. · 2001
• Mutations in ribosomal protein L16 conferring reduced susceptibility to evernimicin (SCH27899): implications for mechanism of action. Antimicrob. Agents Chemother. · 2000