Prostacyclin receptor
Also known as: PRIPR, PTGIR
Function
Receptor for prostacyclin (prostaglandin I2 or PGI2). The activity of this receptor is mediated by G(s) proteins which activate adenylate cyclase.
Classification
- Family (Pfam)
- PF00001 7tm_1
- InterPro
- GPCR_Rhodpsn, GPCR_Rhodpsn_7TM, Prostanoid_rcpt, Prostglndn_IP_rcpt
- Functional cluster
- G Protein-Coupled Receptors
Experimental structures · PDB · 2
A predicted model is available from AlphaFold.
Gene Ontology · 11
- GO:0005829 cytosol
- GO:0005886 plasma membrane
- GO:0005085 guanyl-nucleotide exchange factor activity
- GO:0016501 prostacyclin receptor activity
- GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway
- GO:0007267 cell-cell signaling
- GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
- GO:0006954 inflammatory response
- GO:0010642 negative regulation of platelet-derived growth factor receptor signaling pathway
- GO:0048662 negative regulation of smooth muscle cell proliferation
- GO:0007204 positive regulation of cytosolic calcium ion concentration
Drugs targeting this protein · 9
- TREPROSTINIL agonist
- TREPROSTINIL DIOLAMINE agonist
- SELEXIPAG agonist
- ESUBERAPROST agonist
- RALINEPAG agonist
- ILOPROST agonist
- ILOPROST TROMETHAMINE agonist
- TREPROSTINIL SODIUM agonist
- EPOPROSTENOL SODIUM agonist
Related proteins · sequence + function similarity
- Prostacyclin receptor 0.99
- Prostacyclin receptor 0.98
- Prostacyclin receptor 0.97
- Thromboxane A2 receptor 0.93
- Thromboxane A2 receptor 0.92
- Thromboxane A2 receptor 0.92
- Prostaglandin D2 receptor-like 0.92
- Prostaglandin D2 receptor 0.92
- Thromboxane A2 receptor 0.92
- Prostaglandin D2 receptor 0.91
- Prostaglandin D2 receptor 0.91
- Prostaglandin D2 receptor 0.89
Literature · 9 cited papers
- PMID 27613955 J. Biol. Chem. · 2016
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
- Role of extracellular cysteine residues in dimerization/oligomerization of the human prostacyclin receptor. Eur. J. Pharmacol. · 2004
- Palmitoylation of the human prostacyclin receptor. Functional implications of palmitoylation and isoprenylation. J. Biol. Chem. · 2003
- Investigation of a functional requirement for isoprenylation by the human prostacyclin receptor. Eur. J. Biochem. · 2002
- Molecular cloning of human prostacyclin receptor cDNA and its gene expression in the cardiovascular system. Circulation · 1994
- Structural organization and chromosomal assignment of the human prostacyclin receptor gene. Genomics · 1995
- Cloning and expression of a cDNA for the human prostacyclin receptor. FEBS Lett. · 1994
- Cloning and expression of a cDNA for the human prostanoid IP receptor. J. Biol. Chem. · 1994
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