Thromboxane A2 receptor
Also known as: TBXA2R
Function
Receptor for thromboxane A2 (TXA2), a potent stimulator of platelet aggregation. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. In the kidney, the binding of TXA2 to glomerular TP receptors causes intense vasoconstriction. Activates phospholipase C.
Classification
- Family (Pfam)
- PF00001 7tm_1
- InterPro
- GPCR_Rhodpsn, GPCR_Rhodpsn_7TM, Prostanoid_rcpt, Thbox_rcpt
- Functional cluster
- Membrane Channels & Lipid-Anchored Proteins
Experimental structures · PDB · 6
A predicted model is available from AlphaFold.
Gene Ontology · 18
- GO:0001669 acrosomal vesicle
- GO:0005886 plasma membrane
- GO:0005085 guanyl-nucleotide exchange factor activity
- GO:0004961 thromboxane A2 receptor activity
- GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway
- GO:0071222 cellular response to lipopolysaccharide
- GO:0007186 G protein-coupled receptor signaling pathway
- GO:0006954 inflammatory response
- GO:0090051 negative regulation of cell migration involved in sprouting angiogenesis
- GO:0045766 positive regulation of angiogenesis
- GO:0030194 positive regulation of blood coagulation
- GO:0045777 positive regulation of blood pressure
- GO:0007204 positive regulation of cytosolic calcium ion concentration
- GO:0045907 positive regulation of vasoconstriction
- GO:0045471 response to ethanol
- GO:0007584 response to nutrient
- GO:0033574 response to testosterone
- GO:0009410 response to xenobiotic stimulus
Disease associations
- bleeding disorder, platelet-type, 13, susceptibility to MONDO:0800447
Drugs targeting this protein · 5
- PICOTAMIDE inhibitor
- TERUTROBAN antagonist
- TERBOGREL antagonist
- RAMATROBAN antagonist
- SERATRODAST antagonist
Related proteins · sequence + function similarity
- Thromboxane A2 receptor 1.00
- Thromboxane A2 receptor 0.99
- Thromboxane A2 receptor 0.99
- Thromboxane A2 receptor 0.97
- Prostaglandin D2 receptor 0.93
- Prostacyclin receptor 0.93
- Prostaglandin D2 receptor-like 0.93
- Prostaglandin D2 receptor 0.93
- Prostacyclin receptor 0.93
- Prostacyclin receptor 0.93
- Prostaglandin D2 receptor 0.92
- Prostaglandin E2 receptor EP3 subtype 0.92
Co-cited proteins · studied together in the literature
- Protein fantom 1 shared papers
- Proteasome subunit alpha type-3 1 shared papers
- Small ribosomal subunit protein RACK1 1 shared papers
Literature · 15 cited papers
- An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J. Proteomics · 2014
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. Sci. Signal. · 2010
- Thromboxane A2-induced signal transduction is negatively regulated by KIAA1005 that directly interacts with thromboxane A2 receptor. Prostaglandins Other Lipid Mediat. · 2009
- RACK1 regulates the cell surface expression of the G protein-coupled receptor for thromboxane A(2). Traffic · 2008
- Low expression of cell-surface thromboxane A2 receptor beta-isoform through the negative regulation of its membrane traffic by proteasomes. Prostaglandins Other Lipid Mediat. · 2007
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
- The DNA sequence and biology of human chromosome 19. Nature · 2004
- Two thromboxane A2 receptor isoforms in human platelets. Opposite coupling to adenylyl cyclase with different sensitivity to Arg60 to Leu mutation. J. Clin. Invest. · 1996
- Point mutation in the seventh hydrophobic domain of the human thromboxane A2 receptor allows discrimination between agonist and antagonist binding sites. Mol. Pharmacol. · 1993
- Characterization and chromosomal mapping of the human thromboxane A2 receptor gene. J. Biol. Chem. · 1993
- Alternative splicing produces a divergent cytoplasmic tail in the human endothelial thromboxane A2 receptor. J. Biol. Chem. · 1994
- Cloning and pharmacologic characterization of a thromboxane A2 receptor from K562 (human chronic myelogenous leukemia) cells. J. Pharmacol. Exp. Ther. · 1994
- … and 3 more in the literature graph
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