Prostaglandin D2 receptor

Function

Receptor for prostaglandin D2 (PGD2). The activity of this receptor is mainly mediated by G(s) proteins that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP. A mobilization of calcium is also observed, but without formation of inositol 1,4,5-trisphosphate (By similarity). Involved in PLA2G3-dependent maturation of mast cells. PLA2G3 is secreted by immature mast cells and acts on nearby fibroblasts upstream to PTDGS to synthesize PGD2, which in turn promotes mast cell maturation and degranulation via PTGDR (By similarity).

Classification

Family (Pfam)

PF00001 7tm_1

InterPro

GPCR_Rhodpsn, GPCR_Rhodpsn_7TM, Pglndn_D_rcpt, Prostanoid_rcpt

Functional cluster

Membrane Channels & Lipid-Anchored Proteins

Experimental structures · PDB · 8

• 8ZVZ EM 2.35A
• 8ZW0 EM 2.72A
• 9AU0 EM 2.45A
• 9E9S EM 2.68A
• 9EE5 EM 2.89A
• 9EI5 EM 2.84A
• 9EKH EM 2.89A
• 9UWD EM 3.41A

A predicted model is available from AlphaFold.

Gene Ontology · 9

• GO:0016020 membrane
• GO:0005886 plasma membrane
• GO:0004956 prostaglandin D receptor activity
• GO:0001785 prostaglandin J receptor activity
• GO:0071799 cellular response to prostaglandin D stimulus
• GO:0007186 G protein-coupled receptor signaling pathway
• GO:0006954 inflammatory response
• GO:0043303 mast cell degranulation
• GO:0007204 positive regulation of cytosolic calcium ion concentration

Disease associations

• asthma-related traits, susceptibility to, 1 MONDO:0011805

Drugs targeting this protein · 3

• VIDUPIPRANT antagonist
• ASAPIPRANT antagonist
• LAROPIPRANT antagonist

Related proteins · sequence + function similarity

• Prostaglandin D2 receptor 0.99
• Prostaglandin D2 receptor-like 0.98
• Prostaglandin D2 receptor 0.98
• Prostaglandin D2 receptor 0.98
• Thromboxane A2 receptor 0.93
• Prostacyclin receptor 0.93
• Thromboxane A2 receptor 0.93
• Prostacyclin receptor 0.93
• Prostacyclin receptor 0.93
• Prostaglandin E2 receptor EP2 subtype 0.93
• Thromboxane A2 receptor 0.93
• Thromboxane A2 receptor 0.92

Co-cited proteins · studied together in the literature

• Prostaglandin D2 receptor-like 1 shared papers
• Prostaglandin D2 receptor 1 shared papers

Literature · 6 cited papers

• Role of prostanoid DP receptor variants in susceptibility to asthma. N. Engl. J. Med. · 2004
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• The DNA sequence and analysis of human chromosome 14. Nature · 2003
• Pharmacology and autoradiography of human DP prostanoid receptors using [(3)H]-BWA868C, a DP receptor-selective antagonist radioligand. Br. J. Pharmacol. · 2000
• Molecular cloning and characterization of the human prostanoid DP receptor. J. Biol. Chem. · 1995
• Pharmacological and cardiovascular properties of a hydantoin derivative, BW 245 C, with high affinity and selectivity for PGD2 receptors. Prostaglandins · 1983