Prostaglandin E2 receptor EP2 subtype
Also known as: PTGER2
Function
Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. The subsequent raise in intracellular cAMP is responsible for the relaxing effect of this receptor on smooth muscle.
Classification
- Family (Pfam)
- PF00001 7tm_1
- InterPro
- GPCR_Rhodpsn, GPCR_Rhodpsn_7TM, Prostanoid_rcpt, Prostglndn_EP2_rcpt
- Functional cluster
- Membrane Transporters & GPCRs
Experimental structures · PDB · 5
A predicted model is available from AlphaFold.
Gene Ontology · 8
- GO:0005886 plasma membrane
- GO:0004957 prostaglandin E receptor activity
- GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway
- GO:0071380 cellular response to prostaglandin E stimulus
- GO:0007186 G protein-coupled receptor signaling pathway
- GO:0006954 inflammatory response
- GO:0007204 positive regulation of cytosolic calcium ion concentration
- GO:0032570 response to progesterone
Drugs targeting this protein · 7
- TAPRENEPAG ISOPROPYL agonist
- SIMENEPAG ISOPROPYL agonist
- OMIDENEPAG agonist
- OMIDENEPAG ISOPROPYL agonist
- ALPROSTADIL agonist
- DINOPROSTONE agonist
- EVATANEPAG agonist
Related proteins · sequence + function similarity
- Prostaglandin E2 receptor EP2 subtype 0.99
- Prostaglandin E2 receptor EP2 subtype 0.99
- Prostaglandin E2 receptor EP2 subtype 0.99
- Prostaglandin D2 receptor 0.94
- Prostaglandin D2 receptor 0.93
- Prostaglandin D2 receptor-like 0.93
- Prostaglandin D2 receptor 0.93
- Prostaglandin D2 receptor 0.92
- Prostaglandin E2 receptor EP3 subtype 0.92
- Prostaglandin E2 receptor EP3 subtype 0.92
- Thromboxane A2 receptor 0.91
- Thromboxane A2 receptor 0.90
Literature · 3 cited papers
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
- Cloning, structural characterization, and chromosomal localization of the gene encoding the human prostaglandin E2 receptor EP2 subtype. Gene · 1999
- Cloning of a novel human prostaglandin receptor with characteristics of the pharmacologically defined EP2 subtype. Mol. Pharmacol. · 1994
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