Prostaglandin E2 receptor EP1 subtype
Also known as: PTGER1
Function
Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(q) proteins which activate a phosphatidylinositol-calcium second messenger system. May play a role as an important modulator of renal function. Implicated the smooth muscle contractile response to PGE2 in various tissues.
Classification
- Family (Pfam)
- PF00001 7tm_1
- InterPro
- GPCR_Rhodpsn, GPCR_Rhodpsn_7TM, Prostanoid_rcpt, Prostglndn_DP_rcpt, Prostglndn_EP1_rcpt
- Functional cluster
- Nucleic Acid Metabolism & Repair Enzymes
Experimental structures · PDB · 1
- 9M1H EM 2.55A
A predicted model is available from AlphaFold.
Gene Ontology · 11
- GO:0005886 plasma membrane
- GO:0031748 D1 dopamine receptor binding
- GO:0004957 prostaglandin E receptor activity
- GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway
- GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway
- GO:0007186 G protein-coupled receptor signaling pathway
- GO:0006954 inflammatory response
- GO:0070256 negative regulation of mucus secretion
- GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway
- GO:0007204 positive regulation of cytosolic calcium ion concentration
- GO:0034695 response to prostaglandin E
Drugs targeting this protein · 3
- ONO-8539 antagonist
- ALPROSTADIL agonist
- DINOPROSTONE agonist
Related proteins · sequence + function similarity
- Prostaglandin E2 receptor EP1 subtype 0.99
- Prostaglandin E2 receptor EP1 subtype 0.98
- Prostaglandin E2 receptor EP1 subtype 0.97
- Sphingosine 1-phosphate receptor 5 0.90
- Sphingosine 1-phosphate receptor 5 0.90
- Sphingosine 1-phosphate receptor 5 0.90
- Sphingosine 1-phosphate receptor 5 0.90
- Thromboxane A2 receptor 0.87
- Prostacyclin receptor 0.86
- Prostacyclin receptor 0.86
- Thromboxane A2 receptor 0.86
- Sphingosine 1-phosphate receptor 4 0.86
Literature · 2 cited papers
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