Sphingosine 1-phosphate receptor 5

Function

Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. Is coupled to both the G(i/0)alpha and G(12) subclass of heteromeric G proteins (By similarity). May play a regulatory role in the transformation of radial glial cells into astrocytes and may affect proliferative activity of these cells.

Classification

Family (Pfam)

PF00001 7tm_1

InterPro

EDG8_S1P_rcpt, GPCR_Rhodpsn, GPCR_Rhodpsn_7TM, S1P_rcpt

Functional cluster

Nucleic Acid Metabolism & Repair Enzymes

Experimental structures · PDB · 2

• 7EW1 EM 3.40A
• 7YXA X-ray 2.20A

A predicted model is available from AlphaFold.

Gene Ontology · 6

• GO:0005737 cytoplasm
• GO:0005886 plasma membrane
• GO:0098793 presynapse
• GO:0004930 G protein-coupled receptor activity
• GO:0038036 sphingosine-1-phosphate receptor activity
• GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway

Drugs targeting this protein · 5

• OZANIMOD modulator
• AMISELIMOD HYDROCHLORIDE modulator
• ETRASIMOD ARGININE modulator
• FINGOLIMOD LAURYL SULFATE binding agent
• FINGOLIMOD HYDROCHLORIDE agonist

Related proteins · sequence + function similarity

• Sphingosine 1-phosphate receptor 5 0.99
• Sphingosine 1-phosphate receptor 5 0.99
• Sphingosine 1-phosphate receptor 5 0.99
• Sphingosine 1-phosphate receptor 4 0.92
• Prostaglandin E2 receptor EP1 subtype 0.90
• Prostaglandin E2 receptor EP1 subtype 0.90
• Probable G protein-coupled receptor 27 0.89
• Probable G protein-coupled receptor 27 0.89
• Probable G protein-coupled receptor 27 0.89
• Prostaglandin E2 receptor EP1 subtype 0.86
• Prostaglandin E2 receptor EP1 subtype 0.86
• G protein-coupled bile acid receptor 1 0.84

Co-cited proteins · studied together in the literature

• Sphingosine 1-phosphate receptor 5 1 shared papers
• Sphingosine 1-phosphate receptor 5 1 shared papers
• Putative vomeronasal receptor-like protein 4 1 shared papers
• Probable G protein-coupled receptor 160 1 shared papers
• Probable G protein-coupled receptor 152 1 shared papers
• Cysteinyl leukotriene receptor 2 1 shared papers
• Probable G protein-coupled receptor 148 1 shared papers
• Putative G protein-coupled receptor GPR32P1 1 shared papers
• Probable G protein-coupled receptor 174 1 shared papers
• Oxoeicosanoid receptor 1 1 shared papers
• GPI ethanolamine phosphate transferase 3, catalytic subunit 1 shared papers
• Transmembrane protein 171 1 shared papers

Literature · 8 cited papers

• Evidence for the presence of the sphingosine-1-phosphate receptor Edg-8 in human radial glial fibers. Acta Histochem. · 2004
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• The DNA sequence and biology of human chromosome 19. Nature · 2004
• Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004
• Characterization of a human sphingosine-1-phosphate receptor gene (S1P5) and its differential expression in LGL leukemia. Biochim. Biophys. Acta · 2002
• Comparative analysis of human and rat S1P(5) (edg8): differential expression profiles and sensitivities to antagonists. Biochem. Pharmacol. · 2002
• Identification of G protein-coupled receptor genes from the human genome sequence. FEBS Lett. · 2002
• Characterization of the human and mouse sphingosine 1-phosphate receptor, S1P5 (Edg-8): structure-activity relationship of sphingosine1-phosphate receptors. Biochemistry · 2001