5-hydroxytryptamine receptor 7

Function

G protein-coupled receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone and a mitogen. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. HTR7 is coupled to G(s) G alpha proteins and mediates activation of adenylate cyclase activity.

Classification

Family (Pfam)

PF00001 7tm_1

InterPro

5HT_7_rcpt, GPCR_Rhodpsn, GPCR_Rhodpsn_7TM

Functional cluster

Membrane Transporters & GPCRs

Experimental structures · PDB · 1

• 7XTC EM 3.20A

A predicted model is available from AlphaFold.

Gene Ontology · 14

• GO:0005929 cilium
• GO:0030425 dendrite
• GO:0005886 plasma membrane
• GO:0045202 synapse
• GO:0032588 trans-Golgi network membrane
• GO:0004993 G protein-coupled serotonin receptor activity
• GO:0030594 neurotransmitter receptor activity
• GO:0007192 adenylate cyclase-activating serotonin receptor signaling pathway
• GO:0008015 blood circulation
• GO:0007268 chemical synaptic transmission
• GO:0007623 circadian rhythm
• GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
• GO:0006939 smooth muscle contraction
• GO:0042310 vasoconstriction

Drugs targeting this protein · 4

• DEXFENFLURAMINE HYDROCHLORIDE agonist
• ZIMELDINE HYDROCHLORIDE antagonist
• AMISULPRIDE antagonist
• JNJ-18038683 antagonist

Related proteins · sequence + function similarity

• 5-hydroxytryptamine receptor 7 0.99
• 5-hydroxytryptamine receptor 7 0.98
• 5-hydroxytryptamine receptor 7 0.98
• 5-hydroxytryptamine receptor 7 0.93
• Orexin receptor type 2 0.82
• Orexin receptor type 2 0.81
• Orexin receptor type 2 0.81
• Probable G protein-coupled receptor 63 0.81
• Probable G protein-coupled receptor 63 0.81
• Orexin receptor type 2 0.81
• G protein-coupled receptor 83 0.80
• Orexin receptor type 2 0.80

Co-cited proteins · studied together in the literature

• 5-hydroxytryptamine receptor 7 1 shared papers
• 5-hydroxytryptamine receptor 4 1 shared papers
• 5-hydroxytryptamine receptor 6 1 shared papers
• Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 1 shared papers
• Guanine nucleotide-binding protein G(s) subunit alpha isoforms short 1 shared papers
• Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 1 shared papers

Literature · 9 cited papers

• GPCRs steer Gi and Gs selectivity via TM5-TM6 switches as revealed by structures of serotonin receptors. Mol. Cell · 2022
• Biochemical and pharmacological study of N-linked glycosylation of the human serotonin 5-HT(7)a receptor. FEBS J. · 2012
• Human protein factory for converting the transcriptome into an in vitro-expressed proteome. Nat. Methods · 2008
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• The DNA sequence and comparative analysis of human chromosome 10. Nature · 2004
• Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004
• The human serotonin 7 (5-HT7) receptor gene: genomic organization and systematic mutation screening in schizophrenia and bipolar affective disorder. Mol. Psychiatry · 1996
• Four 5-hydroxytryptamine7 (5-HT7) receptor isoforms in human and rat produced by alternative splicing: species differences due to altered intron-exon organization. J. Neurochem. · 1997
• Cloning of a novel human serotonin receptor (5-HT7) positively linked to adenylate cyclase. J. Biol. Chem. · 1993