Adenosine receptor A2b
Also known as: ADORA2B
Function
Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
Classification
- Family (Pfam)
- PF00001 7tm_1
- InterPro
- Adeno_A2B_rcpt, Adenosn_rcpt, GPCR_Rhodpsn, GPCR_Rhodpsn_7TM
- Functional cluster
- Membrane Transporters & GPCRs
Experimental structures · PDB · 4
A predicted model is available from AlphaFold.
Gene Ontology · 10
- GO:0098978 glutamatergic synapse
- GO:0005886 plasma membrane
- GO:0098793 presynapse
- GO:0098685 Schaffer collateral - CA1 synapse
- GO:0001609 G protein-coupled adenosine receptor activity
- GO:0007190 activation of adenylate cyclase activity
- GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway
- GO:0007186 G protein-coupled receptor signaling pathway
- GO:0099171 presynaptic modulation of chemical synaptic transmission
- GO:0042311 vasodilation
Drugs targeting this protein · 11
- CAFFEINE antagonist
- OXTRIPHYLLINE antagonist
- CAFFEINE CITRATE antagonist
- THEOPHYLLINE SODIUM GLYCINATE antagonist
- THEOPHYLLINE antagonist
- AMINOPHYLLINE antagonist
- LAS101057 antagonist
- GS 6201 antagonist
- ETRUMADENANT antagonist
- ADENOSINE agonist
- PENTOXIFYLLINE antagonist
Related proteins · sequence + function similarity
- Adenosine receptor A2b 0.99
- Adenosine receptor A2b 0.99
- Adenosine receptor A2b 0.99
- Adenosine receptor A2b 0.99
- Adenosine receptor A2b 0.98
- Adenosine receptor A2a 0.93
- Adenosine receptor A2b 0.92
- Adenosine receptor A2a 0.91
- Adenosine receptor A2a 0.91
- Adenosine receptor A2a 0.91
- Adenosine receptor A2a 0.91
- Adenosine receptor A2a 0.88
Literature · 3 cited papers
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
- Cloning and chromosomal localization of the human A2b adenosine receptor gene (ADORA2B) and its pseudogene. Genomics · 1995
- Molecular cloning and expression of an adenosine A2b receptor from human brain. Biochem. Biophys. Res. Commun. · 1992
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